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Pathophysiology of "cholinoceptor supersensitivity" in affective disorders

dc.contributor.authorDilsaver, Steven C.en_US
dc.date.accessioned2006-04-07T19:29:35Z
dc.date.available2006-04-07T19:29:35Z
dc.date.issued1986-07en_US
dc.identifier.citationDilsaver, Steven C. (1986/07)."Pathophysiology of "cholinoceptor supersensitivity" in affective disorders." Biological Psychiatry 21(8-9): 813-829. <http://hdl.handle.net/2027.42/26130>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T4S-482RG24-F/2/d42439e4dcde00cd2734f5b2bddbd475en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/26130
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3015271&dopt=citationen_US
dc.description.abstractPhenomenological and physiological variables demonstrate supersensitive changes to cholinergic challenge in affective disorder subjects. Theorists generally assume the primary defect is the postsynaptic muscarinic receptor. However, in addition to defectiveness or up-regulation of this receptor, the appearance of postsynaptic "cholinoceptor super-sensitivity" can result from abnormal presynaptic mechanisms, membrane "pathology," derangement of intracystolic mechanisms that amplify effects of receptor-agonist coupling, or aberrant cholinergic-monoaminergic interaction. This article discusses abnormalities of the postsynaptic receptor, regulation of postsynaptic receptor density, the presynaptic muscarinic receptor, and other mechanisms regulating the release of acetylcholine, membrane dynamics, and "cascade" mechanisms--specifically the phosphatidylinositol (PI) cycle, Ca2+ mobilization, and cyclic guanosine monophosphate (GMP) generation--as causes of cholinergic system "supersensitivity." It is suggested that an approach to the topic emphasizing site of abnormality will encourage greater clarity of thought in the study of the cholinergic component of the pathophysiology of affective illness.en_US
dc.format.extent1460292 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePathophysiology of "cholinoceptor supersensitivity" in affective disordersen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPsychiatryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumClinical Studies Unit for Affective Disorders, Department of Psychiatry, Mental Health Research Institute, University of Michigan, Neuroscience Laboratory, Ann Arbor, MI, U.S.A.en_US
dc.identifier.pmid3015271en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/26130/1/0000206.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-3223(86)90246-5en_US
dc.identifier.sourceBiological Psychiatryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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