Pathophysiology of "cholinoceptor supersensitivity" in affective disorders
dc.contributor.author | Dilsaver, Steven C. | en_US |
dc.date.accessioned | 2006-04-07T19:29:35Z | |
dc.date.available | 2006-04-07T19:29:35Z | |
dc.date.issued | 1986-07 | en_US |
dc.identifier.citation | Dilsaver, Steven C. (1986/07)."Pathophysiology of "cholinoceptor supersensitivity" in affective disorders." Biological Psychiatry 21(8-9): 813-829. <http://hdl.handle.net/2027.42/26130> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T4S-482RG24-F/2/d42439e4dcde00cd2734f5b2bddbd475 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26130 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3015271&dopt=citation | en_US |
dc.description.abstract | Phenomenological and physiological variables demonstrate supersensitive changes to cholinergic challenge in affective disorder subjects. Theorists generally assume the primary defect is the postsynaptic muscarinic receptor. However, in addition to defectiveness or up-regulation of this receptor, the appearance of postsynaptic "cholinoceptor super-sensitivity" can result from abnormal presynaptic mechanisms, membrane "pathology," derangement of intracystolic mechanisms that amplify effects of receptor-agonist coupling, or aberrant cholinergic-monoaminergic interaction. This article discusses abnormalities of the postsynaptic receptor, regulation of postsynaptic receptor density, the presynaptic muscarinic receptor, and other mechanisms regulating the release of acetylcholine, membrane dynamics, and "cascade" mechanisms--specifically the phosphatidylinositol (PI) cycle, Ca2+ mobilization, and cyclic guanosine monophosphate (GMP) generation--as causes of cholinergic system "supersensitivity." It is suggested that an approach to the topic emphasizing site of abnormality will encourage greater clarity of thought in the study of the cholinergic component of the pathophysiology of affective illness. | en_US |
dc.format.extent | 1460292 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Pathophysiology of "cholinoceptor supersensitivity" in affective disorders | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Clinical Studies Unit for Affective Disorders, Department of Psychiatry, Mental Health Research Institute, University of Michigan, Neuroscience Laboratory, Ann Arbor, MI, U.S.A. | en_US |
dc.identifier.pmid | 3015271 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26130/1/0000206.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-3223(86)90246-5 | en_US |
dc.identifier.source | Biological Psychiatry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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