Peripheral sympathectomy and adrenal medullectomy do not alter cerebrospinal fluid norepinephrine
dc.contributor.author | Peskind, Elaine R. | en_US |
dc.contributor.author | Raskind, Murray A. | en_US |
dc.contributor.author | Wilkinson, Charles W. | en_US |
dc.contributor.author | Flatness, David E. | en_US |
dc.contributor.author | Halter, Jeffrey B. | en_US |
dc.date.accessioned | 2006-04-07T19:33:19Z | |
dc.date.available | 2006-04-07T19:33:19Z | |
dc.date.issued | 1986-03-05 | en_US |
dc.identifier.citation | Peskind, Elaine R., Raskind, Murray A., Wilkinson, Charles W., Flatness, David E., Halter, Jeffrey B. (1986/03/05)."Peripheral sympathectomy and adrenal medullectomy do not alter cerebrospinal fluid norepinephrine." Brain Research 367(1-2): 258-264. <http://hdl.handle.net/2027.42/26232> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6SYR-4834JXM-Y6/2/96b0944390ea72e761fb45285e83a949 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26232 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3697700&dopt=citation | en_US |
dc.description.abstract | Despite a blood-brain barrier for norepinephrine, the concentration of norepinephrine in plasma and cerebrospinal fluid has been observed to be similar. This relationship between plasma and cerebrospinal fluid norepinephrine levels suggests that peripheral sympathetic neurons innervating blood vessels to brain and spinal cord may contribute significantly to cerebrospinal fluid norepinephrine levels, and questions the validity of cerebrospinal fluid norepinephrine as an index of central nervous system noradrenergic activity. We demonstrate that extensive destruction of the peripheral sympathetic nervous system and the adrenal medulla has no effect on rat cerebrospinal fluid norepinephrine. It is therefore unlikely that peripheral sources of norepinephrine contribute significantly to cerebrospinal fluid norepinephrine levels. | en_US |
dc.format.extent | 629268 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Peripheral sympathectomy and adrenal medullectomy do not alter cerebrospinal fluid norepinephrine | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Geriatric Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | University of Washington School of Medicine, USA; Seattle/American Lake Geriatric Research, Education and Clinical Center (182B), Seattle Veterans Administration Medical Center, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98105, USA; Seattle/American Lake Geriatric Research, Education and Clinical Center (182B), Seattle Veterans Administration Medical Center, USA | en_US |
dc.contributor.affiliationother | Seattle/American Lake Geriatric Research, Education and Clinical Center, American Lake Veterans Administration Medical Center, Tacoma, WA 98493, USA; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98105, USA | en_US |
dc.contributor.affiliationother | Seattle/American Lake Geriatric Research, Education and Clinical Center (182B), Seattle Veterans Administration Medical Center, USA | en_US |
dc.identifier.pmid | 3697700 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26232/1/0000312.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0006-8993(86)91600-8 | en_US |
dc.identifier.source | Brain Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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