Increased body fluid purine levels during hypotensive events : Evidence for ATP degradation
dc.contributor.author | Woolliscroft, James O. | en_US |
dc.contributor.author | Fox, Irving H. | en_US |
dc.date.accessioned | 2006-04-07T19:40:07Z | |
dc.date.available | 2006-04-07T19:40:07Z | |
dc.date.issued | 1986-09 | en_US |
dc.identifier.citation | Woolliscroft, James O., Fox, Irving H. (1986/09)."Increased body fluid purine levels during hypotensive events : Evidence for ATP degradation." The American Journal of Medicine 81(3): 472-478. <http://hdl.handle.net/2027.42/26423> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TDC-4CMYHF3-9Y/2/002e64046a41cf602a9c53236c74d71e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26423 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3752148&dopt=citation | en_US |
dc.description.abstract | Tissue ischemia leads to adenosine triphosphate (ATP) breakdown with elevation of body fluid ATP metabolites. This study tests the hypothesis that there is a direct relationship between periods of hypotension and body fluid uric acid and oxypurine levels in 19 prospectively studied patients. Significant elevations in urine oxypurine/creatinine clearance were found during periods of hypotension as compared with nonhypotensive periods (p <0.05). During severe episodes of hypotension, the serum urate level was significantly elevated as well (p <0.05). The increase in these body fluid products of ATP degradation may reflect cellular ischemia during hypotensive periods. There was a weak correlation (r = -0.31, p <0.001) between the systolic blood pressure and urine oxypurine/creatinine clearance. However, variability in the appearance of body fluid ATP breakdown products during episodes of hypotension suggests the interplay of multiple factors in the degradation of ATP. The use of ATP degradation products to quantitate the physiologic significance of clinical events remains tantalizing but not proved. | en_US |
dc.format.extent | 762093 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Increased body fluid purine levels during hypotensive events : Evidence for ATP degradation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Family Medicine and Primary Care | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Section of General Internal Medicine, and the Clinical Research Center, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Section of General Internal Medicine, and the Clinical Research Center, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.identifier.pmid | 3752148 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26423/1/0000510.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9343(86)90302-5 | en_US |
dc.identifier.source | The American Journal of Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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