Loss of hippocampal [3H]TCP binding in Alzheimer's disease

Maragos, William F.; Chu, Dorothy C. M.; Young, Anne B.; D'Amato, Constance J.; Penney, Jr. , John B.

1987-03-09

Citation: Maragos, William F., Chu, Dorothy C. M., Young, Anne B., D'Amato, Constance J., Penney, Jr., John B. (1987/03/09)."Loss of hippocampal [3H]TCP binding in Alzheimer's disease." Neuroscience Letters 74(3): 371-376. <http://hdl.handle.net/2027.42/26773>

Abstract: We have previously demonstrated a marked loss in (NMDA) receptors in the hippocampus and cerebral cortex of patients dying with dementia of the Alzheimer type (DAT). In addition, we have found that the dissociative anesthetic N-(1-[2-thienyl]cyclohexyl)3,4-piperidine ([3H]TCP) binds to a site whose regional distribution is highly correlated with that of NMDA receptor sites. We studied the binding of [3H]TCP to sections of hippocampi from 8 controls, 12 patients with DAT and 7 patients with other dementias. [3H]TCP binding was significantly reduced in strata pyramidalia of CA1/CA2, CA3 and subiculum of DAT hippocampal formation compared to that of control. Labelled dissociative anestheties could potentially be used with positron emission tomography in the diagnosis of DAT.

DOIs: http://dx.doi.org/10.1016/0304-3940(87)90326-0

PMID: 3031556

URI: http://www.sciencedirect.com/science/article/B6T0G-482RVGV-27/2/1aceb62c11d174a30d929e0cfca1dfb5
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3031556&dopt=citation

Handle: http://hdl.handle.net/2027.42/26773

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