Loss of hippocampal [3H]TCP binding in Alzheimer's disease
dc.contributor.author | Maragos, William F. | en_US |
dc.contributor.author | Chu, Dorothy C. M. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.contributor.author | D'Amato, Constance J. | en_US |
dc.contributor.author | Penney, Jr. , John B. | en_US |
dc.date.accessioned | 2006-04-07T19:55:51Z | |
dc.date.available | 2006-04-07T19:55:51Z | |
dc.date.issued | 1987-03-09 | en_US |
dc.identifier.citation | Maragos, William F., Chu, Dorothy C. M., Young, Anne B., D'Amato, Constance J., Penney, Jr., John B. (1987/03/09)."Loss of hippocampal [3H]TCP binding in Alzheimer's disease." Neuroscience Letters 74(3): 371-376. <http://hdl.handle.net/2027.42/26773> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-482RVGV-27/2/1aceb62c11d174a30d929e0cfca1dfb5 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/26773 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3031556&dopt=citation | en_US |
dc.description.abstract | We have previously demonstrated a marked loss in (NMDA) receptors in the hippocampus and cerebral cortex of patients dying with dementia of the Alzheimer type (DAT). In addition, we have found that the dissociative anesthetic N-(1-[2-thienyl]cyclohexyl)3,4-piperidine ([3H]TCP) binds to a site whose regional distribution is highly correlated with that of NMDA receptor sites. We studied the binding of [3H]TCP to sections of hippocampi from 8 controls, 12 patients with DAT and 7 patients with other dementias. [3H]TCP binding was significantly reduced in strata pyramidalia of CA1/CA2, CA3 and subiculum of DAT hippocampal formation compared to that of control. Labelled dissociative anestheties could potentially be used with positron emission tomography in the diagnosis of DAT. | en_US |
dc.format.extent | 414772 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Loss of hippocampal [3H]TCP binding in Alzheimer's disease | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of the Neuroscience Program, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, Ann Arbor, MI 48104, U.S.A. | en_US |
dc.identifier.pmid | 3031556 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/26773/1/0000325.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(87)90326-0 | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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