Identification of sequence changes in the cold-adapted, live attenuated influenzavaccine strain, A/Ann Arbor/6/60 (H2N2)
dc.contributor.author | Cox, Nancy J. | en_US |
dc.contributor.author | Kitame, Fumio | en_US |
dc.contributor.author | Kendal, Alan P. | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.contributor.author | Naeve, Clayton W. | en_US |
dc.date.accessioned | 2006-04-07T20:07:53Z | |
dc.date.available | 2006-04-07T20:07:53Z | |
dc.date.issued | 1988-12 | en_US |
dc.identifier.citation | Cox, Nancy J., Kitame, Fumio, Kendal, Alan P., Maassab, Hunein F., Naeve, Clayton (1988/12)."Identification of sequence changes in the cold-adapted, live attenuated influenzavaccine strain, A/Ann Arbor/6/60 (H2N2)." Virology 167(2): 554-567. <http://hdl.handle.net/2027.42/27049> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WXR-4G3DJSY-X/2/6c109500a57891b087184b546df9955f | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27049 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2974219&dopt=citation | en_US |
dc.description.abstract | Nucleotide sequences have been obtained for RNA segments encoding the 13132, P131, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative that has been used for preparing investigational live attenuated vaccines. Twenty-four nucleotide differences between the ca and wt viruses were detected, of which 11 were deduced to code for amino acid substitutions in the ca virus proteins. One amino acid substitution each was predicted for the PB2, M2, and NS1 proteins. Two amino acid substitutions were predicted for the NP and the PA proteins. Four substitutions were predicted for the PB1 protein. The biological significance of mutations in the PB2, PB1, PA, and M2 genes of the ca virus is suggested by currently available genetic data, a comparison with other available influenza gene sequences, and the nature of the predicted amino acid changes. In addition, the sequence data confirm the close evolutionary relationship between the genomes of influenza A (H2N2) and influenza A (H3N2) viruses. | en_US |
dc.format.extent | 1346698 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Identification of sequence changes in the cold-adapted, live attenuated influenzavaccine strain, A/Ann Arbor/6/60 (H2N2) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48104, USA | en_US |
dc.contributor.affiliationother | Influenza Branch, Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333, USA | en_US |
dc.contributor.affiliationother | Department of Bacteriology, Yamagata University, School of Medicine, Zao-Iida, Yamagata 990-23, Japan | en_US |
dc.contributor.affiliationother | Influenza Branch, Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333, USA | en_US |
dc.contributor.affiliationother | Department of Virology,St. Jude Children's Hospital for Research, 322 N. Lauderdale, Memphis, TN 38 101, USA | en_US |
dc.identifier.pmid | 2974219 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27049/1/0000039.pdf | en_US |
dc.identifier.source | Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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