Involvement of 1,25-dihydroxyvitamin D3 in regulating myocardial calcium metabolism: Physiological and pathological actions

Abstract

The role of the prohormone vitamin D3 in regulating calcium and phosphate metabolism in the intestine, kidney, and bone has been known for several decades [1]. Recent studies have provided evidence that vitamin D3, may also play an important role in regulating metabolism in other organs, including heart [2]. This role has been suggested by the identification of a specific receptor for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, in these tissues [3-5], as well as the presence of a 1.25(OH)2D3-dependent calcium binding protein [6, 7].Although administration of excessive quantities of vitamin D3 has been shown in many studies to produce myocardial calcinosis and heart failure [8, 9], the importance of vitamin D3 in regulating myocardial metabolism under normal conditions has only recently been demonstrated [10, 11]. The purpose of the present review is to assess the current status of research regarding the pathological and physiological actions of vitamin D3 on the heart. The initial section of this report will focus on the pathological effects of excessive vitamin D3 on cardiovascular function, while the latter sections will describe recent studies related to the involvement of 1,25(OH)2D3 in regulating calcium homeostasis in ventricular cells and the relationship between vitamin D3 and myocardial contractility.