View Item 

Show simple item record

Physical mapping of the cystic fibrosis region by pulsed-field gel electrophoresis

dc.contributor.authorDrumm, Mitchell L.en_US
dc.contributor.authorSmith, Cassandra L.en_US
dc.contributor.authorDean, Michaelen_US
dc.contributor.authorCole, Jeffery L.en_US
dc.contributor.authorIannuzzi, Michael C.en_US
dc.contributor.authorCollins, Francis S.en_US
dc.date.accessioned2006-04-07T20:19:42Z
dc.date.available2006-04-07T20:19:42Z
dc.date.issued1988-05en_US
dc.identifier.citationDrumm, Mitchell L., Smith, Cassandra L., Dean, Michael, Cole, Jeffery L., Iannuzzi, Michael C., Collins, Francis S. (1988/05)."Physical mapping of the cystic fibrosis region by pulsed-field gel electrophoresis." Genomics 2(4): 346-354. <http://hdl.handle.net/2027.42/27317>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DYM8X6-97/2/55f83e4b00b606624ea99cdfd15d229een_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27317
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2851537&dopt=citationen_US
dc.description.abstractThe gene for cystic fibrosis (CF) is known to be flanked by the closely linked DNA markers met and J3.11 on chromosome 7. Using the technique of pulsed-field gel electrophoresis, we have constructed a complete overlapping restriction map of approximately 3000 kb of DNA in this regions. The met and J3.11 probes are found to be between 1300 and 1800 kb apart, which compares well with their genetic distance of 1-2 cM. The CF gene must be located within this interval, and the availability of this physical map should be of considerable utility in mapping additional clones as the search for the gene proceeds.en_US
dc.format.extent1990335 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePhysical mapping of the cystic fibrosis region by pulsed-field gel electrophoresisen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of the Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of the Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of the Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of the Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherDepartment of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York 10032, USAen_US
dc.contributor.affiliationotherBiological Carcinogenesis Development Program, Program Resource Incorporated, Frederick Cancer Research Facility, Frederick, Maryland 21701, USAen_US
dc.identifier.pmid2851537en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27317/1/0000339.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(88)90024-9en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000339.pdf
Size:
1.898MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.