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Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene

dc.contributor.authorKhani, Shahrokh C.en_US
dc.contributor.authorPorter, Todd D.en_US
dc.contributor.authorCoon, Minor J.en_US
dc.date.accessioned2006-04-07T20:25:17Z
dc.date.available2006-04-07T20:25:17Z
dc.date.issued1988-01-15en_US
dc.identifier.citationKhani, Shahrokh C., Porter, Todd D., Coon, Minor J. (1988/01/15)."Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene." Biochemical and Biophysical Research Communications 150(1): 10-17. <http://hdl.handle.net/2027.42/27427>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4F031HH-1SY/2/e21a057c6b2f5bba7dfd5d961ab38b89en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27427
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2827660&dopt=citationen_US
dc.description.abstractTwo genes that hybridize to the cDNA for alcohol-inducible cytochrome P-450 form 3a (P-450ALC) have been isolated from a rabbit genomic library and characterized by restriction mapping, hybridization, and partial sequence analysis. The genes show extensive sequence similarity as judged by hybridization at high stringency to the coding region of P-450 3a cDNA. However, only gene 1 hybridizes under these conditions to the 3' nontranslated segment of P-450 3a cDNA. The hybridizing fragments derived from both cloned genes were found to be present in the genome of all rabbits examined by Southern blot analysis, indicating that the genes represent separate loci and are not polymorphic alleles. Partial sequence analysis indicated that gene 1 encodes P-450 3a. Gene 2, if transcribed, would encode a protein with greater than 96% sequence identity with P-450 3a in the NH2-terminal region.en_US
dc.format.extent867676 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleIsolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related geneen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Biological Chemistry, Medical School, The University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid2827660en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27427/1/0000465.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(88)90479-2en_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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