Systemic hormonal and physiological abnormalities in anxiety disorders
dc.contributor.author | Cameron, Oliver G. | en_US |
dc.contributor.author | Nesse, Randolph M. | en_US |
dc.date.accessioned | 2006-04-07T20:30:43Z | |
dc.date.available | 2006-04-07T20:30:43Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Cameron, Oliver G., Nesse, Randolph M. (1988)."Systemic hormonal and physiological abnormalities in anxiety disorders." Psychoneuroendocrinology 13(4): 287-307. <http://hdl.handle.net/2027.42/27526> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TBX-485YHS1-52/2/c1dfb65c77e32f7db2287d9ab27e711c | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27526 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2906440&dopt=citation | en_US |
dc.description.abstract | Among the studies of systemic hormonal and physiological abnormalities associated with anxiety disorders, the most consistent and extensive findings suggest (a) peripheral adrenergic hyperactivity (including increases in norepinephrine but not epinephrine) and functional dysregulation, (b) increased incidence of mitral valve prolapse in panic patients, and (c) normal suppressibility of the hypothalamic-pituitary-adrenal cortical endocrine system with dexamethasone in panic patients. Other less-certain findings include (a) increased circulating concentrations of plasma ACTH and/or cortisol, and prolactin, in panic patients, (b) increased platelet monoamine oxidase activity in generalized anxiety and/or panic patients, (c) decreased gonadal axis activity in some anxious individuals, (d) decreased nighttime melatonin plasma concentrations in panic patients, and (e) peripheral [alpha]2 and [beta]-adrenoreceptor down-regulation, with normal serotonin binding parameters. These findings, taken together, provide tentative support for dysfunction in adrenergic and GABAergic central nervous system mechanisms in people with anxiety disorders. Abnormal anxiety and normal stress both show evidence of adrenergic hyperactivity; however, there appear to be differences in hormonal profiles, especially the apparent lack of increase of epinephrine during panic attacks, as well as differences in the reactivity of the system, and in the "trigger" mechanisms which determine when the response occurs. | en_US |
dc.format.extent | 1735057 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Systemic hormonal and physiological abnormalities in anxiety disorders | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan, U.S.A. | en_US |
dc.identifier.pmid | 2906440 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27526/1/0000570.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0306-4530(88)90054-6 | en_US |
dc.identifier.source | Psychoneuroendocrinology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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