View Item 

Show simple item record

Routine synthesis of N-[11C-methyl]scopolamine by phosphite mediated reductive methylation with [11C]formaldehyde

dc.contributor.authorMulholland, G. Keithen_US
dc.contributor.authorJewett, Douglas M.en_US
dc.contributor.authorToorongian, Steven A.en_US
dc.date.accessioned2006-04-07T20:31:56Z
dc.date.available2006-04-07T20:31:56Z
dc.date.issued1988en_US
dc.identifier.citationMulholland, G. Keith, Jewett, Douglas M., Toorongian, Steven A. (1988)."Routine synthesis of N-[11C-methyl]scopolamine by phosphite mediated reductive methylation with [11C]formaldehyde." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 39(5): 373-379. <http://hdl.handle.net/2027.42/27552>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6X3S-46Y3JPK-W5/2/2badbe37637df6002c78cbcc5488abbben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27552
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2840412&dopt=citationen_US
dc.description.abstractA synthesis of [11C]scopolamine capable of clinical delivery of this agent in high specific activity is described. The precursor [11C]formaldehyde was produced by catalytic oxidation of [11C]CH3OH over metallic silver and was used to N-11C-methylate norscopolamine using aqueous neutral potassium phosphite as the reducing agent. The labeling reaction was complete after 5 min at 75-80[deg]C and the [11C]scopolamine (99% radiochemical purity) was isolated by preparative HPLC. Total synthesis time is less than 45 min. Decay corrected radiochemical yields from [11C]CO2 are presently 20-43%.en_US
dc.format.extent622161 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleRoutine synthesis of N-[11C-methyl]scopolamine by phosphite mediated reductive methylation with [11C]formaldehydeen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.contributor.affiliationumDivision of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A.en_US
dc.identifier.pmid2840412en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27552/1/0000596.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0883-2889(88)90065-2en_US
dc.identifier.sourceInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
0000596.pdf
Size:
607.5KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.