Routine synthesis of N-[11C-methyl]scopolamine by phosphite mediated reductive methylation with [11C]formaldehyde
dc.contributor.author | Mulholland, G. Keith | en_US |
dc.contributor.author | Jewett, Douglas M. | en_US |
dc.contributor.author | Toorongian, Steven A. | en_US |
dc.date.accessioned | 2006-04-07T20:31:56Z | |
dc.date.available | 2006-04-07T20:31:56Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Mulholland, G. Keith, Jewett, Douglas M., Toorongian, Steven A. (1988)."Routine synthesis of N-[11C-methyl]scopolamine by phosphite mediated reductive methylation with [11C]formaldehyde." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 39(5): 373-379. <http://hdl.handle.net/2027.42/27552> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6X3S-46Y3JPK-W5/2/2badbe37637df6002c78cbcc5488abbb | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27552 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2840412&dopt=citation | en_US |
dc.description.abstract | A synthesis of [11C]scopolamine capable of clinical delivery of this agent in high specific activity is described. The precursor [11C]formaldehyde was produced by catalytic oxidation of [11C]CH3OH over metallic silver and was used to N-11C-methylate norscopolamine using aqueous neutral potassium phosphite as the reducing agent. The labeling reaction was complete after 5 min at 75-80[deg]C and the [11C]scopolamine (99% radiochemical purity) was isolated by preparative HPLC. Total synthesis time is less than 45 min. Decay corrected radiochemical yields from [11C]CO2 are presently 20-43%. | en_US |
dc.format.extent | 622161 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Routine synthesis of N-[11C-methyl]scopolamine by phosphite mediated reductive methylation with [11C]formaldehyde | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Nuclear Engineering and Radiological Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.identifier.pmid | 2840412 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27552/1/0000596.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0883-2889(88)90065-2 | en_US |
dc.identifier.source | International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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