Multiphase extraction: Rapid phase-transfer of [18F]fluoride ion for nucleophilic radiolabeling reactions
dc.contributor.author | Jewett, Douglas M. | en_US |
dc.contributor.author | Toorongian, Steven A. | en_US |
dc.contributor.author | Mulholland, G. Keith | en_US |
dc.contributor.author | Watkins, G. Leonard | en_US |
dc.contributor.author | Kilbourn, Michael R. | en_US |
dc.date.accessioned | 2006-04-07T20:33:51Z | |
dc.date.available | 2006-04-07T20:33:51Z | |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Jewett, Douglas M., Toorongian, Steven A., Mulholland, G. Keith, Watkins, G. Leonard, Kilbourn, Michael R. (1988)."Multiphase extraction: Rapid phase-transfer of [18F]fluoride ion for nucleophilic radiolabeling reactions." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 39(11): 1109-1111. <http://hdl.handle.net/2027.42/27603> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6X3S-46WWK9N-53/2/b874afdd8cf938f0e3c204de1986b36c | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27603 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2850283&dopt=citation | en_US |
dc.description.abstract | In multiphase extraction [18F]fluoride ion for radiolabeling is recovered from target water by passage through a small column of microporous polymer impregnated with a lipophilic cryptand or quaternary ammonium salt. The 18O enriched water can be recovered for reuse. The [18F]fluoride ion-pair is eluted from the column by a small volume of acetonitrile or other organic solvent. Evaporation of the acetonitrile removes traces of water to yield a reactive ion pair for nucleophilic radiofluorination reactions. A wide range of ion-pairs based on K+ or NH4+ cryptands or quaternary ammonium salts can be employed. The method was applied to the synthesis of [18F]FDG. | en_US |
dc.format.extent | 331237 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Multiphase extraction: Rapid phase-transfer of [18F]fluoride ion for nucleophilic radiolabeling reactions | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Nuclear Engineering and Radiological Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0552, U.S.A. | en_US |
dc.contributor.affiliationother | no department found | en_US |
dc.identifier.pmid | 2850283 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27603/1/0000647.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0883-2889(88)90001-9 | en_US |
dc.identifier.source | International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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