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Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs

dc.contributor.authorTurk, Steven R.en_US
dc.contributor.authorKik, Natalie A.en_US
dc.contributor.authorBirch, Gary M.en_US
dc.contributor.authorChiego, Jr. , Daniel J.en_US
dc.contributor.authorShipman, Jr. , C.en_US
dc.date.accessioned2006-04-07T20:38:38Z
dc.date.available2006-04-07T20:38:38Z
dc.date.issued1989-12en_US
dc.identifier.citationTurk, Steven R., Kik, Natalie A., Birch, Gary M., Chiego, Jr., Daniel J., Shipman, Jr., C. (1989/12)."Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs." Virology 173(2): 733-735. <http://hdl.handle.net/2027.42/27674>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WXR-4BKB9B9-2W/2/fa8619b9396575b8201250a06e7f9fa7en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27674
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2556851&dopt=citationen_US
dc.description.abstractTwo herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6[Delta], produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.en_US
dc.format.extent3587915 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleHerpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDepartment of Biologic and Materials Sciences, School of Dentistry The University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Microbiology and Immunology, School of Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA.en_US
dc.identifier.pmid2556851en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27674/1/0000057.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0042-6822(89)90588-6en_US
dc.identifier.sourceVirologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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