Sister-chromatid exchange and chromosome aberrations for 4 aliphatic epoxides in mice
dc.contributor.author | Giri, A. K. | en_US |
dc.contributor.author | Messerly, E. A. | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.date.accessioned | 2006-04-07T20:40:49Z | |
dc.date.available | 2006-04-07T20:40:49Z | |
dc.date.issued | 1989-10 | en_US |
dc.identifier.citation | Giri, A. K., Messerly, E. A., Sinsheimer, J. E. (1989/10)."Sister-chromatid exchange and chromosome aberrations for 4 aliphatic epoxides in mice." Mutation Research/Genetic Toxicology 224(2): 253-261. <http://hdl.handle.net/2027.42/27732> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B73FB-475BXYC-M/2/6014d6314b8875247a8307f29125c451 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27732 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2677710&dopt=citation | en_US |
dc.description.abstract | Sister-chromatid exchange (SCE) and chromosome aberrations (CA) in bone marrow cells were analyzed after in vivo exposure in mice to 4 aliphatic epoxides, namely 1-naphthyl glycidyl ether (NGE), 1-naphthyl propylene oxide (NPO), 4-nitrophenyl glycidyl ether (NPGE) and trichloropropylene oxide (TCPO). These compounds were selected as being among the most mutagenic aliphatic epoxides in our previous structure-mutagenicity studies with the Ames test. There were significant dose-related increases in SCE and CA results for all 4 epoxides. The order of genotoxicity as established through SCE was NGE > NPO > NPGE [congruent with] TCPO > solvent control. It is of interest that Ames Salmonella results are consistent with in vivo genotoxicity for these compounds. However, only the plate test version of the Ames procedure is consistent with this order of in vivo genotoxicity and neither preincubation Ames testing results nor chemical alkylation rates would have predicted this order. | en_US |
dc.format.extent | 668481 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Sister-chromatid exchange and chromosome aberrations for 4 aliphatic epoxides in mice | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, U.S.A. | en_US |
dc.identifier.pmid | 2677710 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27732/1/0000124.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0165-1218(89)90164-X | en_US |
dc.identifier.source | Mutation Research/Genetic Toxicology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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