McDonald, John W.; Uckele, John E.; Silverstein, Faye Sarah; Johnston, Michael V.
1989-09-25
Citation:McDonald, John W., Uckele, John, Silverstein, Faye S., Johnston, Michael V. (1989/09/25)."HA-996 (1-hydroxy-3-aminopyrrolidone-2) selectively reduces (NMDA)-mediated brain damage." Neuroscience Letters 104(1-2): 167-170. <http://hdl.handle.net/2027.42/27755>
Abstract: The neuroprotective effects of the strychnine-insensitive glycine receptor antagonist, HA-966, against (NMDA)- and quisqualate (QA)-mediated brain injury were determined in perinatal rats. Postnatal day (PND) 7 rats received intrastriatal injections of NMDA (25 nmol) or QA (100 nmol) and then were administered intraperitoneal (i.p.) injections of varying doses of HA-966 or vehicle 15 min later. Animals were sacrificed 5 days later and the degree of brain injury was calculated by comparison of the weights of injected and contralateral cerebral hemispheres. HA-966 selectively reduced the degree of NMDA-mediated brain injury in a dose-dependent manner. However, HA-966 did not attenuate QA-mediated brain injury.
