The potential role of serum ferritin in the pathogenesis of acquired immune deficiency syndrome (AIDS)

Abstract

Elevated serum ferritin levels have been observed in several disease states including various malignancies, inflammatory states, and the acquired immunodeficiency syndrome (AIDS). This discussion will examine the normal sequence of events in T cell activation and proliferation, as well as the various defects in these events, and monocyte/macrophage and NK cell activity seen in AIDS patients. Further, the potential role of a serum suppressor factor as a contributor to the profound immunosuppression seen in AIDS will be discussed, as will evidence suggesting that ferritin may be this factor. A model is presented to explain mechanisms by which ferritin might suppress immune function and further studies to elaborate these mechanisms are proposed.