The effect of intravenous immunoglobulin on the in vitro function of human neutrophils
dc.contributor.author | Lawton, John W. M. | en_US |
dc.contributor.author | Robinson, J. Paul | en_US |
dc.contributor.author | Till, Gerd O. | en_US |
dc.date.accessioned | 2006-04-07T20:42:07Z | |
dc.date.available | 2006-04-07T20:42:07Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Lawton, John W. M., Robinson, J. Paul, Till, Gerd O. (1989)."The effect of intravenous immunoglobulin on the in vitro function of human neutrophils." Immunopharmacology 18(2): 97-105. <http://hdl.handle.net/2027.42/27767> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T27-4772GXW-4/2/bcb391cd1d35c1bfdc64d4f96935fcdb | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27767 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2553642&dopt=citation | en_US |
dc.description.abstract | Three commercially available preparations of human immunoglobulin for intravenous use (IVIgG), namely Gamimune N, Sandoglobulin and Intraglobin F, were tested for their ability to modulate human neutrophil function in vitro. IVIgG consistently stimulated the neutrophil respiratory burst at concentrations of 0.5 to 1 mg/ml, concentrations readily achieved in vivo by moderate-dose therapy. Superoxide (O2-) release was increased by 3.5-4.5 nmol per 5 x 105 cells at these concentrations of IVIgG, and H2O2 production increased in a dose-dependent fashion up to 8 mg/ml IVIgG. Luminol-dependent chemiluminescence (CL) was also directly stimulated by IVIgG. In addition, the effects of both soluble and particulate stimulators (N-formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate and opsonized zymosan) on the neutrophil respiratory burst were enhanced by IVIgG. In a filter assay of neutrophil migration, using a modified Boyden chamber, no consistent effect on neutrophil locomotion or chemotaxis could be demonstrated. The effect of IVIgG on neutrophil metabolism may contribute to its beneficial therapeutic effect in severe, life-threatening infections. | en_US |
dc.format.extent | 653887 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The effect of intravenous immunoglobulin on the in vitro function of human neutrophils | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, MI, U.S.A. | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, MI, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Hong Kong, Hong Kong, China | en_US |
dc.identifier.pmid | 2553642 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27767/1/0000161.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0162-3109(89)90062-3 | en_US |
dc.identifier.source | Immunopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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