5-bromo-2'-deoxyuridine incorporation into DNA in hepatic VX2 tumor-bearing rabbits,
dc.contributor.author | Knol, James A. | en_US |
dc.contributor.author | Stetson, Philip L. | en_US |
dc.contributor.author | Wagner, John G. | en_US |
dc.contributor.author | Johnson, Norma J. | en_US |
dc.contributor.author | Yang, Zhaomin | en_US |
dc.contributor.author | Prieskorn, Diane | en_US |
dc.contributor.author | Terrio, Patricia | en_US |
dc.contributor.author | Knutsen, Conrad A. | en_US |
dc.contributor.author | Ensminger, William D. | en_US |
dc.date.accessioned | 2006-04-07T20:43:42Z | |
dc.date.available | 2006-04-07T20:43:42Z | |
dc.date.issued | 1989-08 | en_US |
dc.identifier.citation | Knol, James A., Stetson, Philip L., Wagner, John G., Johnson, Norma J., Yang, Zhaomin, Prieskorn, Diane, Terrio, Patricia, Knutsen, Conrad A., Ensminger, William D. (1989/08)."5-bromo-2'-deoxyuridine incorporation into DNA in hepatic VX2 tumor-bearing rabbits,." Journal of Surgical Research 47(2): 112-116. <http://hdl.handle.net/2027.42/27807> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WM6-4BNF2Y8-265/2/ffdd3e24786580f08a4991e6ed4a4116 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27807 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2755115&dopt=citation | en_US |
dc.description.abstract | The halogenated pyrimidine 5-bromo-2'-deoxyuridine (BrdUrd) possesses both radiosensitizing and antimetabolite effects through its incorporation as a thymidine analog in replicating DNA. To evaluate the regional advantage for treatment of hepatic malignancy by hepatic arterial infusion, BrdUrd was infused into either the hepatic artery (HA) or a central vein (iv) in 26 rabbits with intrahepatic VX2 tumor. After a 24-hr constant rate infusion of 10, 20, or 40 mg/kg/24 hr, the percentage BrdUrd incorporation into the DNA of bone marrow, duodenal mucosa, liver, and hepatic VX2 tumor was measured by gas chromatography/mass spectrometry methods. VX2 tumor BrdUrd incorporation was greater by HA than by iv routes (P P < 0.05). At appropriate dose rates, hepatic arterial administration of BrdUrd provides a regional advantage for DNA BrdUrd incorporation in the rabbit intrahepatic VX2 tumor. | en_US |
dc.format.extent | 689299 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | 5-bromo-2'-deoxyuridine incorporation into DNA in hepatic VX2 tumor-bearing rabbits, | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | School of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan, USA. | en_US |
dc.identifier.pmid | 2755115 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27807/1/0000212.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-4804(89)90072-3 | en_US |
dc.identifier.source | Journal of Surgical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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