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Huntington disease: No evidence for locus heterogeneity

dc.contributor.authorConneally, P. Michaelen_US
dc.contributor.authorHaines, Jonathan L.en_US
dc.contributor.authorTanzi, Rudolph E.en_US
dc.contributor.authorWexler, Nancy S.en_US
dc.contributor.authorPenchaszadeh, Graciela K.en_US
dc.contributor.authorHarper, Peter S.en_US
dc.contributor.authorFolstein, Susan E.en_US
dc.contributor.authorCassiman, Jean J.en_US
dc.contributor.authorMyers, Richard H.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.date.accessioned2006-04-07T20:44:32Z
dc.date.available2006-04-07T20:44:32Z
dc.date.issued1989-08en_US
dc.identifier.citationConneally, P. Michael, Haines, Jonathan L., Tanzi, Rudolf E., Wexler, Nancy S., Penchaszadeh, Graciela K., Harper, Peter S., Folstein, Susan E., Cassiman, Jean J., Myers, Richard H., Young, Anne B. (1989/08)."Huntington disease: No evidence for locus heterogeneity." Genomics 5(2): 304-308. <http://hdl.handle.net/2027.42/27823>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DNHPRS-9G/2/c122db5be3308b0be723cd149560ea93en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/27823
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2571579&dopt=citationen_US
dc.description.abstractA total of 63 families with Huntington disease (HD) were examined for linkage between HD and G8 (D4S10). The families included 57 Caucasian, four Black American, and two Japanese. The combined maximum lod score was 87.69 at [theta] = 0.04 (99% confidence interval 0.018-0.071). The maximum frequency of recombination was 0.03 in males and 0.05 in females. Fifty-seven families gave positive lod scores; five small families gave mildly negative lod scores. The maximum likelihood estimate of [alpha], the proportion of linked loci, was 1.0 with a lower 99% confidence interval of 0.88. These data suggest that there is only one HD locus, although a second rare locus cannot be ruled out.en_US
dc.format.extent559533 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleHuntington disease: No evidence for locus heterogeneityen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumNeuroscience Laboratory, University of Michigan, Ann Arbor, Michigan 48104, USAen_US
dc.contributor.affiliationotherDepartment of Medical Genetics, Indiana University Medical Center, Indianapolis, Indiana 46223, USAen_US
dc.contributor.affiliationotherNeurogenetics Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USAen_US
dc.contributor.affiliationotherNeurogenetics Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USAen_US
dc.contributor.affiliationotherPsychiatric Institute, Columbia University, New York, New York 10032, USAen_US
dc.contributor.affiliationotherPsychiatric Institute, Columbia University, New York, New York 10032, USAen_US
dc.contributor.affiliationotherInstitute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, United Kingdomen_US
dc.contributor.affiliationotherDepartment of Psychiatry, Johns Hopkins Hospital, Baltimore, Maryland 21205, USAen_US
dc.contributor.affiliationotherCenter of Human Genetics, University of Leuven, B 3008, Leuven, Belgiumen_US
dc.contributor.affiliationotherDepartment of Neurology, Boston University Medical Center, Boston, Massachusetts 02118, USAen_US
dc.identifier.pmid2571579en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/27823/1/0000229.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(89)90062-1en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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