Huntington disease: No evidence for locus heterogeneity
dc.contributor.author | Conneally, P. Michael | en_US |
dc.contributor.author | Haines, Jonathan L. | en_US |
dc.contributor.author | Tanzi, Rudolph E. | en_US |
dc.contributor.author | Wexler, Nancy S. | en_US |
dc.contributor.author | Penchaszadeh, Graciela K. | en_US |
dc.contributor.author | Harper, Peter S. | en_US |
dc.contributor.author | Folstein, Susan E. | en_US |
dc.contributor.author | Cassiman, Jean J. | en_US |
dc.contributor.author | Myers, Richard H. | en_US |
dc.contributor.author | Young, Anne B. | en_US |
dc.date.accessioned | 2006-04-07T20:44:32Z | |
dc.date.available | 2006-04-07T20:44:32Z | |
dc.date.issued | 1989-08 | en_US |
dc.identifier.citation | Conneally, P. Michael, Haines, Jonathan L., Tanzi, Rudolf E., Wexler, Nancy S., Penchaszadeh, Graciela K., Harper, Peter S., Folstein, Susan E., Cassiman, Jean J., Myers, Richard H., Young, Anne B. (1989/08)."Huntington disease: No evidence for locus heterogeneity." Genomics 5(2): 304-308. <http://hdl.handle.net/2027.42/27823> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DNHPRS-9G/2/c122db5be3308b0be723cd149560ea93 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/27823 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2571579&dopt=citation | en_US |
dc.description.abstract | A total of 63 families with Huntington disease (HD) were examined for linkage between HD and G8 (D4S10). The families included 57 Caucasian, four Black American, and two Japanese. The combined maximum lod score was 87.69 at [theta] = 0.04 (99% confidence interval 0.018-0.071). The maximum frequency of recombination was 0.03 in males and 0.05 in females. Fifty-seven families gave positive lod scores; five small families gave mildly negative lod scores. The maximum likelihood estimate of [alpha], the proportion of linked loci, was 1.0 with a lower 99% confidence interval of 0.88. These data suggest that there is only one HD locus, although a second rare locus cannot be ruled out. | en_US |
dc.format.extent | 559533 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Huntington disease: No evidence for locus heterogeneity | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Neuroscience Laboratory, University of Michigan, Ann Arbor, Michigan 48104, USA | en_US |
dc.contributor.affiliationother | Department of Medical Genetics, Indiana University Medical Center, Indianapolis, Indiana 46223, USA | en_US |
dc.contributor.affiliationother | Neurogenetics Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA | en_US |
dc.contributor.affiliationother | Neurogenetics Laboratory, Massachusetts General Hospital, Boston, Massachusetts 02114, USA | en_US |
dc.contributor.affiliationother | Psychiatric Institute, Columbia University, New York, New York 10032, USA | en_US |
dc.contributor.affiliationother | Psychiatric Institute, Columbia University, New York, New York 10032, USA | en_US |
dc.contributor.affiliationother | Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, United Kingdom | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA | en_US |
dc.contributor.affiliationother | Center of Human Genetics, University of Leuven, B 3008, Leuven, Belgium | en_US |
dc.contributor.affiliationother | Department of Neurology, Boston University Medical Center, Boston, Massachusetts 02118, USA | en_US |
dc.identifier.pmid | 2571579 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/27823/1/0000229.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(89)90062-1 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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