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Synthesis of 11C-labelled thymidine for tumor visualization using positron emission tomography

dc.contributor.authorPoupeye, E.en_US
dc.contributor.authorCounsell, Raymond E.en_US
dc.contributor.authorDe Leenheer, A.en_US
dc.contributor.authorSlegers, G.en_US
dc.contributor.authorGoethals, P.en_US
dc.date.accessioned2006-04-07T20:56:03Z
dc.date.available2006-04-07T20:56:03Z
dc.date.issued1989en_US
dc.identifier.citationPoupeye, E., Counsell, R. E., De Leenheer, A., Slegers, G., Goethals, P. (1989)."Synthesis of 11C-labelled thymidine for tumor visualization using positron emission tomography." International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 40(1): 57-61. <http://hdl.handle.net/2027.42/28118>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6X3S-46Y3F0T-73/2/63ffd6e5c49ac768a232e4aadcf4dfb1en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28118
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2540122&dopt=citationen_US
dc.description.abstractA no-carrier added synthesis of [11C]thymidine from cyclotron produced [11C]methyl iodide is presented. The bis-silylated derivative of the lithium salt of 5-bromo-2'-deoxyuridine is treated with [11C]methyl iodide in THF at -50[deg]C giving 20-30 mCi [11C]thymidine in a 40-70% radiochemical yield. Purification is performed by reversed phase chromatography on a C18 column. The whole procedure takes 25 min and the specific activity is about 20-30 mCi/[mu]mol at the end of the synthesis.en_US
dc.format.extent415930 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSynthesis of 11C-labelled thymidine for tumor visualization using positron emission tomographyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, M 6322 Medical Science Building 1, The University of Michigan, Medical School, Ann Arbor, MI 48109-0624, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, M 6322 Medical Science Building 1, The University of Michigan, Medical School, Ann Arbor, MI 48109-0624, U.S.A.en_US
dc.contributor.affiliationotherLaboratoria voor Medische Biochemie en voor Klinische Analyse, Rijksuniversiteit Gent, Harelbekestraat 72, B-9000, Gent, Belgiumen_US
dc.contributor.affiliationotherLaboratorium voor Analytische Chemie, Faculteit Farmaceutische Wetenschappen, Rijksuniversiteit Gent, Harelbekestraat 72, B-9000, Gent, Belgiumen_US
dc.contributor.affiliationotherInstituut voor Nucleaire Wetenschappen, Faculteit Farmaceutische Wetenschappen, Rijksuniversiteit Gent, Harelbekestraat 72, B-9000, Gent, Belgiumen_US
dc.identifier.pmid2540122en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28118/1/0000567.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0883-2889(89)90174-3en_US
dc.identifier.sourceInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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