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Gas chromatographic determination of gallopamil and norgallopamil in human plasma

dc.contributor.authorRuggirello, Donald A.en_US
dc.contributor.authorNoonan, Patrick K.en_US
dc.contributor.authorGonzalez, Mario A.en_US
dc.contributor.authorHo, Paulen_US
dc.contributor.authorWagner, John G.en_US
dc.date.accessioned2006-04-07T20:56:12Z
dc.date.available2006-04-07T20:56:12Z
dc.date.issued1989en_US
dc.identifier.citationRuggirello, Donald A., Noonan, Patrick K., Gonzalez, Mario A., Ho, Paul, Wagner, John G. (1989)."Gas chromatographic determination of gallopamil and norgallopamil in human plasma." Journal of Chromatography B: Biomedical Sciences and Applications 487(): 73-80. <http://hdl.handle.net/2027.42/28122>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6TG9-44BNNGK-44/2/418793e27182981ae29acd5c4477f388en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28122
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2715276&dopt=citationen_US
dc.description.abstractA highly sensitive gas chromatographic assay is described for the simultaneous determination of gallopamil, a calcium channel blocking agent, and its major metabolite, norgallopamil. A multi-step extraction procedure is employed followed by on-column capillary gas chromatographic analysis using nitrogen-selective detection. Acetylation of norgallopamil is performed to enable accurate quantification of the metabolite. Linearity was achieved over the range 1-50 ng/ml for both analytes. Assay specificity, precision and accuracy were investigated.en_US
dc.format.extent508786 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGas chromatographic determination of gallopamil and norgallopamil in human plasmaen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelChemistryen_US
dc.subject.hlbsecondlevelChemical Engineeringen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, c/o Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109 U.S.A.en_US
dc.contributor.affiliationumUniversity of Michigan, c/o Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109 U.S.A.en_US
dc.contributor.affiliationotherDepartment of Biopharmaceutics, Schering Research, 1500 S.W. 66th Avenue, Pembroke Pines, FL 33023 U.S.A.en_US
dc.contributor.affiliationotherDepartment of Biopharmaceutics, Schering Research, 1500 S.W. 66th Avenue, Pembroke Pines, FL 33023 U.S.A.en_US
dc.contributor.affiliationotherDepartment of Biopharmaceutics, Schering Research, 1500 S.W. 66th Avenue, Pembroke Pines, FL 33023 U.S.A.en_US
dc.identifier.pmid2715276en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28122/1/0000572.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/S0378-4347(00)83008-Xen_US
dc.identifier.sourceJournal of Chromatography B: Biomedical Sciences and Applicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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