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The functional anatomy of basal ganglia disorders

dc.contributor.authorAlbin, Roger L.en_US
dc.contributor.authorYoung, Anne B.en_US
dc.contributor.authorPenney, John B.en_US
dc.date.accessioned2006-04-07T20:58:35Z
dc.date.available2006-04-07T20:58:35Z
dc.date.issued1989en_US
dc.identifier.citationAlbin, Roger L., Young, Anne B., Penney, John B. (1989)."The functional anatomy of basal ganglia disorders." Trends in Neurosciences 12(10): 366-375. <http://hdl.handle.net/2027.42/28186>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0V-485YNVV-7W/2/c50a1fdd7e89d9658b9fc77ea1f37513en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28186
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2479133&dopt=citationen_US
dc.description.abstractBasal ganglia disorders are a heterogeneous group of clinical syndromes with a common anatomic locus within the basal ganglia. To account for the variety of clinical manifestations associated with insults to various parts of the basal ganglia we propose a model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons. This model is based on a synthesis of experimental animal and post-mortem human anatomic and neurochemical data. Hyperkinetic disorders, which are characterized by an excess of abnormal movements, are postulated to result from the selective impairment of striatal neurons projecting to the lateral globus pallidus. Hypokinetic disorders, such as Parkinson's disease, are hypothesized to result from a complex series of changes in the activity of striatal projection neuron subpopulations resulting in an increase in basal ganglia output. This model suggests that the activity of subpopulations of striatal projection neurons is differentially regulated by striatal afferents and that different striatal projection neuron subpopulations may mediate different aspects of motor control.en_US
dc.format.extent1436599 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleThe functional anatomy of basal ganglia disordersen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, MI 48109, USAen_US
dc.identifier.pmid2479133en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28186/1/0000638.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0166-2236(89)90074-Xen_US
dc.identifier.sourceTrends in Neurosciencesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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