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Metabolic fate of the heart agent [18F]6-fluorometaraminol

dc.contributor.authorRosenspire, Karen C.en_US
dc.contributor.authorGildersleeve, David L.en_US
dc.contributor.authorMassin, Christopher C.en_US
dc.contributor.authorMislankar, Suresh G.en_US
dc.contributor.authorWieland, Donald M.en_US
dc.date.accessioned2006-04-07T21:00:08Z
dc.date.available2006-04-07T21:00:08Z
dc.date.issued1989en_US
dc.identifier.citationRosenspire, Karen C., Gildersleeve, David L., Massin, Christopher C., Mislankar, Suresh G., Wieland, Donald M. (1989)."Metabolic fate of the heart agent [18F]6-fluorometaraminol." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 16(7): 735-739. <http://hdl.handle.net/2027.42/28226>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B7GH9-4D4KGWH-1F/2/82494f3c87d33722755247661436e2eeen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28226
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2613530&dopt=citationen_US
dc.description.abstractStudies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig were injected with 18F-FMR and tissue samples were analyzed for metabolites by HPLC. Liver contained the most metabolites of the tissues studied with 25-90% of the radioactivity present as metabolites at 1 h in all the species studied. While metabolites of 18F-FMR are found in blood, no significant accumulation of these metabolites is found in heart ([les]0.3%) 1 h after i.v. administration in any species except rat. These studies suggest that 18F-FMR is a suitable agent for quantitative imaging of the heart by positron emission tomography.en_US
dc.format.extent516184 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMetabolic fate of the heart agent [18F]6-fluorometaraminolen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI 48109, U.S.A.en_US
dc.identifier.pmid2613530en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28226/1/0000679.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0883-2897(89)90147-5en_US
dc.identifier.sourceInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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