Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS
dc.contributor.author | van Horne, Craig G. | en_US |
dc.contributor.author | Bement, Spencer L. | en_US |
dc.contributor.author | Hoffer, Barry J. | en_US |
dc.contributor.author | Gerhardt, Greg A. | en_US |
dc.date.accessioned | 2006-04-10T13:32:10Z | |
dc.date.available | 2006-04-10T13:32:10Z | |
dc.date.issued | 1990-12-11 | en_US |
dc.identifier.citation | van Horne, Craig G., Bement, Spencer, Hoffer, Barry J., Gerhardt, Greg A. (1990/12/11)."Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS." Neuroscience Letters 120(2): 249-252. <http://hdl.handle.net/2027.42/28273> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T0G-482XYV6-B1/2/f6dccb3e0364b2d4db4bf25274cea6cd | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28273 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2293112&dopt=citation | en_US |
dc.description.abstract | Five-channel silicon-based microprobes were sputter-coated with carbon, coated with Nafion, and used for both in vivo electrochemical and single-unit electrophysiological recordings. High-speed electrochemical studies were performed in vitro and in vivo, which demonstrated that these multisite probes were capable of monitoring the evoked overflow of monoamines in selected brain regions of the rat. In addition, action potentials from Purkinje cells in the rat cerebellum, identified electrophysiologically, were recorded from different sites on the same probe. Spontaneous firing rates could be monitored for up to 2 hours in order to investigate the effects of systemic administration of phencyclidine. These results provide preliminary evidence that solid-state multi-site probes can be utilized for both in vivo electrochemical and electrophysiological studies in the rat brain. | en_US |
dc.format.extent | 405852 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A.; Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A.; Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80262, U.S.A. | en_US |
dc.identifier.pmid | 2293112 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28273/1/0000022.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0304-3940(90)90051-A | en_US |
dc.identifier.source | Neuroscience Letters | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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