Spatial distribution of neural activity evoked by electrical stimulation of the cochlea
dc.contributor.author | Ryan, Allen F. | en_US |
dc.contributor.author | Miller, Josef M. | en_US |
dc.contributor.author | Zhi-Xian Wang, | en_US |
dc.contributor.author | Woolf, Nigel K. | en_US |
dc.date.accessioned | 2006-04-10T13:32:20Z | |
dc.date.available | 2006-04-10T13:32:20Z | |
dc.date.issued | 1990-12 | en_US |
dc.identifier.citation | Ryan, Allen F., Miller, Josef M., Zhi-Xian Wang, , Woolf, Nigel K. (1990/12)."Spatial distribution of neural activity evoked by electrical stimulation of the cochlea." Hearing Research 50(1-2): 57-70. <http://hdl.handle.net/2027.42/28277> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-4864MHN-6R/2/d253752d1d2670eac36d8045d319f4e2 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28277 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2076983&dopt=citation | en_US |
dc.description.abstract | Activity in the central auditory system was mapped with 2-deoxyglucose (2-DG) autoradiography, using either pure tones or electrical stimulation of the normal cochlea. Electrical stimulation with both monopolar (distant reference electrode) and bipolar prostheses near threshold increased 2-DG uptake in auditory nuclei in a manner similar to that seen with a pure tone: increased 2-DG uptake was restricted to a small frequency region of brainstem and mid-brain auditory nuclei. The position of this area was related to the cochlear location of the prosthesis. At higher current amplitudes only the bipolar prosthesis retained spatial restriction of evoked neural activity, while stimulation through a monopolar prosthesis produced evoked activity in all frequency regions of auditory nuclei and in non-auditory nuclei. Activation of non-auditory structures was consistent with spread of current through the brainstem, rather than activation of peripheral nerves. At all current amplitudes, a monopolar prosthesis evoked higher levels of 2-DG uptake than a bipolar prosthesis.The results suggest that while a bipolar prosthesis provides greater spatial restriction of evoked neural activity and a greater dynamic range, a monopolar prosthesis produces higher levels of evoked activity. | en_US |
dc.format.extent | 1924287 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Spatial distribution of neural activity evoked by electrical stimulation of the cochlea | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationother | Department of Surgery/Otolaryngology, UCSD School of Medicine and VA Medical Center, La Jolla, California, USA; Department of Neurosciences, UCSD School of Medicine and VA Medical Center, La Jolla, California, USA. | en_US |
dc.contributor.affiliationother | Department of Experimental Pathology, Institute of Hygiene, Tianjin, People's Republic of China | en_US |
dc.contributor.affiliationother | Department of Surgery/Otolaryngology, UCSD School of Medicine and VA Medical Center, La Jolla, California, USA | en_US |
dc.identifier.pmid | 2076983 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28277/1/0000029.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(90)90033-L | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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