The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
dc.contributor.author | Ballester, Roymarie | en_US |
dc.contributor.author | Marchuk, Douglas A. | en_US |
dc.contributor.author | Boguski, Mark | en_US |
dc.contributor.author | Saulino, Ann M. | en_US |
dc.contributor.author | Letcher, Roxanne | en_US |
dc.contributor.author | Wigler, Michael | en_US |
dc.contributor.author | Collins, Francis S. | en_US |
dc.date.accessioned | 2006-04-10T13:33:32Z | |
dc.date.available | 2006-04-10T13:33:32Z | |
dc.date.issued | 1990-11-16 | en_US |
dc.identifier.citation | Ballester, Roymarie, Marchuk, Douglas, Boguski, Mark, Saulino, Ann, Letcher, Roxanne, Wigler, Michael, Collins, Francis (1990/11/16)."The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins." Cell 63(4): 851-859. <http://hdl.handle.net/2027.42/28307> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WSN-4C5911C-9S/2/bcefb9688a8dd515ae158e21ca221da6 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28307 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2121371&dopt=citation | en_US |
dc.description.abstract | The von Recklinghausen neurofibromatosis locus, NF1, encodes a protein with homology restricted to the catalytic region of the RAS GTPase-activating protein, GAP, and with extensive homology to the IRA1 and IRA2 gene products of the yeast S. cerevisiae. A segment of the NF1 cDNA gene, expressed in yeast, can complement loss of IRA function and can inhibit both wild-type and mutant activated human H-ras genes that are coexpressed in yeast. Yeast expressing the NF1 segment have increased H-ras GTPase-stimulating activity. These studies indicate that the NF1 gene product can interact with RAS proteins and demonstrate structural and functional similarities and differences among the GAP, IRA1, IRA2, and NF1 proteins. | en_US |
dc.format.extent | 1916112 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and the Department of Human Genetics University of Michigan, Ann Arbor, Michigan 48109, USA; National Center for Biotechnology Information National Library of Medicine National Institutes of Health, Bethesda, Maryland 20894, USA. | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and the Department of Internal Medicine University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and the Department of Human Genetics University of Michigan, Ann Arbor, Michigan 48109, USA; National Center for Biotechnology Information National Library of Medicine National Institutes of Health, Bethesda, Maryland 20894, USA. | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and the Department of Human Genetics University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and the Department of Human Genetics University of Michigan, Ann Arbor, Michigan 48109, USA; National Center for Biotechnology Information National Library of Medicine National Institutes of Health, Bethesda, Maryland 20894, USA. | en_US |
dc.contributor.affiliationother | Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA | en_US |
dc.contributor.affiliationother | Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA | en_US |
dc.identifier.pmid | 2121371 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28307/1/0000061.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0092-8674(90)90151-4 | en_US |
dc.identifier.source | Cell | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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