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Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes

dc.contributor.authorBecker, Michael A.en_US
dc.contributor.authorHeidler, Steven A.en_US
dc.contributor.authorBell, Graeme I.en_US
dc.contributor.authorSeino, Susumuen_US
dc.contributor.authorLe Beau, Michelle M.en_US
dc.contributor.authorWestbrook, Carol A.en_US
dc.contributor.authorNeuman, Wilmaen_US
dc.contributor.authorShapiro, Larry J.en_US
dc.contributor.authorMohandas, T. K.en_US
dc.contributor.authorRoessler, Blake J.en_US
dc.contributor.authorPalella, Thomas D.en_US
dc.date.accessioned2006-04-10T13:34:41Z
dc.date.available2006-04-10T13:34:41Z
dc.date.issued1990-11en_US
dc.identifier.citationBecker, Michael A., Heidler, Steven A., Bell, Graeme I., Seino, Susumu, Le Beau, Michelle M., Westbrook, Carol A., Neuman, Wilma, Shapiro, Larry J., Mohandas, T. K., Roessler, Blake J., Palella, Thomas D. (1990/11)."Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes." Genomics 8(3): 555-561. <http://hdl.handle.net/2027.42/28336>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DXK9Y3-M/2/e8e0f420dc6dc3bf7c034021d83f4415en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28336
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1962753&dopt=citationen_US
dc.description.abstractCloned cDNAs representing the entire, homologous (80%) translated sequences of human phosphoribosylpyrophosphate synthetase (PRS) 1 and PRS 2 cDNAs were utilized as probes to localize the corresponding human PRPS1 and PRPS2 genes, previously reported to be X chromosome linked. PRPS1 and PRPS2 loci mapped to the intervals Xq22-q24 and Xp22.2-p22.3, respectively, using a combination of in situ chromosomal hybridization and human x rodent somatic cell panel genomic DNA hybridization analyses. A PRPS1-related gene or pseudogene (PRPS1L2) was also identified using in situ chromosomal hybridization at 9q33-q34. Human HPRT and PRPS1 loci are not closely linked. Despite marked cDNA and deduced amino acid sequence homology, human PRS 1 and PRS 2 isoforms are encoded by genes widely separated on the X chromosome.en_US
dc.format.extent1015774 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleCloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 49104, USA; Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA.en_US
dc.contributor.affiliationotherDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USAen_US
dc.contributor.affiliationotherDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USAen_US
dc.contributor.affiliationotherHoward Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USAen_US
dc.contributor.affiliationotherDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USAen_US
dc.contributor.affiliationotherDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USAen_US
dc.contributor.affiliationotherDepartment of Medicine, University of Chicago, Chicago, Illinois 60637, USAen_US
dc.contributor.affiliationotherDepartment of Biological Chemistry, Harbor-UCLA Medical Center, Torrance, California 90509, USA; Howard Hughes Medical Institute, Harbor-UCLA Medical Center, Torrance, California 90509, USA; Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.en_US
dc.contributor.affiliationotherHoward Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90509, USAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, California 90509, USAen_US
dc.identifier.pmid1962753en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28336/1/0000095.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(90)90043-Ten_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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