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Gastroduodenal mucosal damage with salsalate versus aspirin: Results of experimental models and endoscopic studies in humans

dc.contributor.authorScheiman, James M.en_US
dc.contributor.authorElta, Grace H.en_US
dc.date.accessioned2006-04-10T13:35:40Z
dc.date.available2006-04-10T13:35:40Z
dc.date.issued1990-10en_US
dc.identifier.citationScheiman, James M., Elta, Grace H. (1990/10)."Gastroduodenal mucosal damage with salsalate versus aspirin: Results of experimental models and endoscopic studies in humans." Seminars in Arthritis and Rheumatism 20(2): 121-127. <http://hdl.handle.net/2027.42/28361>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WWX-4C0MJ6D-43/2/e2c3a3c5ae7fd42745abc22c416bd0e5en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28361
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2123561&dopt=citationen_US
dc.description.abstractAnimal models have identified multiple mechanisms of aspirin toxicity. Aspirin inhibits cyclooxygenase in the gastroduodenal mucosa leading to a decrease in endogenous prostaglandins. Prostaglandin mediated mucus and bicarbonate secretion, epithelial hydrophobicity, blood flow, and cellular proliferation are all decreased. Salicylates may cause direct cellular toxicity via inhibition of energy metabolism and membrane transport properties. Salicylate preparations have been designed to decrease gastroduodenal absorption. Endoscopic studies in humans have confirmed that buffering of aspirin does not ameliorate damage, but enteric coating does. Salicylsalicylic acid (salsalate) is an effective antirheumatic drug that bypasses gastric absorption and also avoids cyclooxygenase inhibition. In a randomized, single-blind, endoscopic comparison of salsalate versus enteric-coated aspirin, significantly less gastroduodenal damage was observed in volunteers after salsalate administration compared to enteric-coated aspirin. An endoscopic study in rheumatoid arthritics also confirmed the ability of salsalate to spare gastroduodenal mucosa when compared to naproxen administration. Salsalate may cause less gastroduodenal damage than entericcoated aspirin based on the results of animal models and endoscopic studies in humans.en_US
dc.format.extent740712 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGastroduodenal mucosal damage with salsalate versus aspirin: Results of experimental models and endoscopic studies in humansen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelObstetrics and Gynecologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Medical School, USAen_US
dc.contributor.affiliationumUniversity of Michigan Medical School, USAen_US
dc.identifier.pmid2123561en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28361/1/0000126.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0049-0172(90)90025-Ben_US
dc.identifier.sourceSeminars in Arthritis and Rheumatismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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