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Pentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigs

dc.contributor.authorColeman, J. K. M.en_US
dc.contributor.authorQuirk, Wayne S.en_US
dc.contributor.authorDengerink, Harold A.en_US
dc.contributor.authorWright, J. W.en_US
dc.date.accessioned2006-04-10T13:38:56Z
dc.date.available2006-04-10T13:38:56Z
dc.date.issued1990-08-01en_US
dc.identifier.citationColeman, J. K. M., Quirk, W. S., Dengerink, H. A., Wright, J. W. (1990/08/01)."Pentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigs." Hearing Research 47(1-2): 169-174. <http://hdl.handle.net/2027.42/28442>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T73-4864N9H-CW/2/9f401821420e649c77de1fd8a6338119en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28442
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2228793&dopt=citationen_US
dc.description.abstractThe effects of pentoxifylline on cochlear blood flow (CoBF) were investigated in anesthetized guinea pigs by laser Doppler flowmetry and intravital microscopy red blood cell velocity measurement. Intra-arterial infusion of pentoxifylline (3, 4, and 5 mg/kg/min) produced dose-dependent reductions in blood pressure, accompanied by significant elevations in CoBF that were not dose-dependent. These results are in general agreement with previous findings from our laboratory utilizing normotensive and spontaneously hypertensive rats, however, in contrast with rats, guinea pigs revealed an initial decrease in CoBF followed by an increase. Also, pentoxifylline produced relatively smaller elevations in CoBF in guinea pigs as compared with those previously reported in rats. Taken together these results support the hypothesis that pentoxifylline increases vascular perfusion by decreasing blood viscosity and increasing the plasticity of red blood cells.en_US
dc.format.extent606222 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePentoxifylline increases cochlear blood flow while decreasing blood pressure in guinea pigsen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumKresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Psychology, Washington State University, Pullman, Washington, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Psychology, Washington State University, Pullman, Washington, U.S.A.en_US
dc.contributor.affiliationotherDepartment of Psychology, Washington State University, Pullman, Washington, U.S.A.en_US
dc.identifier.pmid2228793en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28442/1/0000229.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0378-5955(90)90174-Nen_US
dc.identifier.sourceHearing Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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