Show simple item record

[beta]-Hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus

dc.contributor.authorD'Alecy, Louis G.en_US
dc.contributor.authorLundy, Edward F.en_US
dc.contributor.authorKluger, Matthew J.en_US
dc.contributor.authorHarker, Christian T.en_US
dc.contributor.authorLeMay, Daniel R.en_US
dc.contributor.authorShlafer, Marshalen_US
dc.date.accessioned2006-04-10T13:54:29Z
dc.date.available2006-04-10T13:54:29Z
dc.date.issued1990en_US
dc.identifier.citationD'Alecy, Louis G., Lundy, Edward F., Kluger, Matthew J., Harker, Christian T., LeMay, Daniel R., Shlafer, Marshal (1990)."[beta]-Hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 96(1): 189-193. <http://hdl.handle.net/2027.42/28833>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T2R-47F6YKC-11/2/c174249797e948ad480a1beb4d5dab5aen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/28833
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2364670&dopt=citationen_US
dc.description.abstract1. 1. Previous studies have suggested that elevated ketone levels are associated with increased survival time in rodents exposed to hypoxia. In this study the association between whole blood BHB ([beta]-hydroxybutyrate) and hypoxic surivaval time was investigated in hibernating and non-hibernating ground squirrels and in rats.2. 2. Non-hibernating ground squirrels and rats were exposed to hypoxia (4.5% O2). One hundred per cent of ground squirrels survived 1 hr of hypoxia vs 20% of rats.3. 3. Ketone levels were significantly higher in ground squirrels than rats during hypoxia, and rats surviving the longest had the highest ketone levels. 4. When hibernation was induced in ground squirrels there was a significant increase in [beta]-hydroxybutyrate from 0.45 to 1.6 mM (P = 0.0005).4. 5. Ground squirrel heart mitochondrial respiratory control ratios and ATP synthesis rates indicated no preferential ketone utilization which might suggest a possible extramitochondrial role of BHB during hypoxia.5. 6. We conclude that elevated blood BHB levels are associated with increased hypoxic survival and they may have evolved in response to life-threatening hypoxia as experienced during hibernation.en_US
dc.format.extent466654 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.title[beta]-Hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatusen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelKinesiology and Sportsen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Physiology, The University of Michigan School of Medicine, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartments of Pharmacology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USAen_US
dc.identifier.pmid2364670en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/28833/1/0000668.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0305-0491(90)90361-Ven_US
dc.identifier.sourceComparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.