[beta]-Hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus
dc.contributor.author | D'Alecy, Louis G. | en_US |
dc.contributor.author | Lundy, Edward F. | en_US |
dc.contributor.author | Kluger, Matthew J. | en_US |
dc.contributor.author | Harker, Christian T. | en_US |
dc.contributor.author | LeMay, Daniel R. | en_US |
dc.contributor.author | Shlafer, Marshal | en_US |
dc.date.accessioned | 2006-04-10T13:54:29Z | |
dc.date.available | 2006-04-10T13:54:29Z | |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | D'Alecy, Louis G., Lundy, Edward F., Kluger, Matthew J., Harker, Christian T., LeMay, Daniel R., Shlafer, Marshal (1990)."[beta]-Hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 96(1): 189-193. <http://hdl.handle.net/2027.42/28833> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T2R-47F6YKC-11/2/c174249797e948ad480a1beb4d5dab5a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/28833 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2364670&dopt=citation | en_US |
dc.description.abstract | 1. 1. Previous studies have suggested that elevated ketone levels are associated with increased survival time in rodents exposed to hypoxia. In this study the association between whole blood BHB ([beta]-hydroxybutyrate) and hypoxic surivaval time was investigated in hibernating and non-hibernating ground squirrels and in rats.2. 2. Non-hibernating ground squirrels and rats were exposed to hypoxia (4.5% O2). One hundred per cent of ground squirrels survived 1 hr of hypoxia vs 20% of rats.3. 3. Ketone levels were significantly higher in ground squirrels than rats during hypoxia, and rats surviving the longest had the highest ketone levels. 4. When hibernation was induced in ground squirrels there was a significant increase in [beta]-hydroxybutyrate from 0.45 to 1.6 mM (P = 0.0005).4. 5. Ground squirrel heart mitochondrial respiratory control ratios and ATP synthesis rates indicated no preferential ketone utilization which might suggest a possible extramitochondrial role of BHB during hypoxia.5. 6. We conclude that elevated blood BHB levels are associated with increased hypoxic survival and they may have evolved in response to life-threatening hypoxia as experienced during hibernation. | en_US |
dc.format.extent | 466654 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | [beta]-Hydroxybutyrate and response to hypoxia in the ground squirrel, Spermophilus tridecimlineatus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Physiology, The University of Michigan School of Medicine, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Physiology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Departments of Pharmacology and Surgery, The University of Michigan School of Medicine, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 2364670 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/28833/1/0000668.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0305-0491(90)90361-V | en_US |
dc.identifier.source | Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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