Routine production of 2-deoxy-2-[18F]fluoro--glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin

Toorongian, Steven A.; Mulholland, G. Keith; Jewett, Douglas M.; Bachelor, Michael A.; Kilbourn, Michael R.

1990

Citation: Toorongian, Steven A., Mulholland, G. Keith, Jewett, Douglas M., Bachelor, Michael A., Kilbourn, Michael R. (1990)."Routine production of 2-deoxy-2-[18F]fluoro--glucose by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 17(3): 273-279. <http://hdl.handle.net/2027.42/28859>

Abstract: Resin-supported [18F]fluoride ion has been prepared and applied to a rapid, convenient synthesis of [18F]FDG. "No-carrier-added" [18F]fluoride ion is collected on a quaternary 4-(N, N-dialkylamino)-pyridinium functionalized polystyrene anion exchange resin directly from a [18O]water target, dried by rinsing with acetonitrile, and then reacted with 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-[beta]--mannopyrannose. Acidic hydrolysis yields [18F]FDG in a synthesis time of 40 min with overall yields presently averaging above 50%.

DOIs: http://dx.doi.org/10.1016/0883-2897(90)90052-3

PMID: 2341282

URI: http://www.sciencedirect.com/science/article/B7GH9-4C00P0K-DF/2/c4cc6d7381549f11e7746cb47ffcbcec
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2341282&dopt=citation

Handle: http://hdl.handle.net/2027.42/28859

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