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Biology of the impaired endothelium

dc.contributor.authorNabel, Elizabeth G.en_US
dc.date.accessioned2006-04-10T14:31:09Z
dc.date.available2006-04-10T14:31:09Z
dc.date.issued1991-11-04en_US
dc.identifier.citationNabel, Elizabeth G. (1991/11/04)."Biology of the impaired endothelium." The American Journal of Cardiology 68(12): 6-8. <http://hdl.handle.net/2027.42/29035>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T10-4C76C7N-MN/2/d4d306d6d0998f3401b1e027986a5ce9en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29035
dc.description.abstractThe endothelium is a regulatory organ that mediates hemostasis, contractility, cellular proliferation, and inflammatory mechanisms in the vessel wall. Injury to the endothelium from hypertension, smoking, hyperlipidemia, and diabetes mellitus disrupts normal regulatory properties and results in abnormal endothelial cell function. Clinically, endothelial cell dysfunction can be manifested as vasospasm, thrombus formation, atherosclerosis, or restenosis. The normal hemostatic properties of the endothelium include the maintenance of a nonadhesive luminal surface, antithrombotic properties, anticoagulant properties, and fibrinolytic properties. The endothelial cell regulates smooth muscle cell contractility by the production of relaxing and constricting factors in response to physiologic stimuli. Endothelial cell injury is also an initial event in the development of atherosclerosis and restenosis by facilitating platelet adhesion and aggregation and by signaling the release of mitogens from platelets, macrophages, and endothelial cells, which stimulate smooth muscle cell proliferation. In addition, endothelial cells undergo morphologic and functional alterations in response to cytokine signals, which may contribute to the pathogenesis of vasculitis and atherosclerosis. In sum, the normal endothelium performs many regulatory functions which become altered when the endothelium is injured.en_US
dc.format.extent337866 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBiology of the impaired endotheliumen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29035/1/0000068.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0002-9149(91)90217-9en_US
dc.identifier.sourceThe American Journal of Cardiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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