Gene transfer into cardiac myocytes in vivo
dc.contributor.author | Leinwand, Leslie A. | en_US |
dc.contributor.author | Leiden, Jeffrey M. | en_US |
dc.date.accessioned | 2006-04-10T14:34:07Z | |
dc.date.available | 2006-04-10T14:34:07Z | |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Leinwand, Leslie A., Leiden, Jeffrey M. (1991)."Gene transfer into cardiac myocytes in vivo." Trends in Cardiovascular Medicine 1(7): 271-276. <http://hdl.handle.net/2027.42/29104> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1D-4BWVW91-26/2/2d38c0c1e3537918d86f79b7e551ec50 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29104 | |
dc.description.abstract | The ability to express recombinant genes in cardiac myocytes in vivo holds promise for the treatment of a number of inherited and acquired diseases of the cardiovascular system. Several groups have demonstrated recently that plasmid DNA is taken up and expressed in cardiac myocytes following injection into the left ventricular wall in vivo. Recombinant genes introduced into cardiac myocytes by this technique are expressed for at least 6 months after injection, and appear to be regulated normally by humoral signals. In addition to its potential for somatic gene therapy, this method should prove useful for studies of transcriptional regulation in the heart. | en_US |
dc.format.extent | 982144 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Gene transfer into cardiac myocytes in vivo | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute and the Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA | en_US |
dc.identifier.pmid | 21239293 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29104/1/0000142.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/1050-1738(91)90042-D | en_US |
dc.identifier.source | Trends in Cardiovascular Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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