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Molecular cloning of the human histamine H2 receptor

dc.contributor.authorGantz, Iraen_US
dc.contributor.authorMunzert, Gerden_US
dc.contributor.authorTashiro, Takaoen_US
dc.contributor.authorSchaffer, Matthiasen_US
dc.contributor.authorWang, Lidongen_US
dc.contributor.authorDelValle, Johnen_US
dc.contributor.authorYamada, Tadatakaen_US
dc.date.accessioned2006-04-10T14:37:03Z
dc.date.available2006-04-10T14:37:03Z
dc.date.issued1991-08-15en_US
dc.identifier.citationGantz, Ira, Munzert, Gerd, Tashiro, Takao, Schaffer, Matthias, Wang, Lidong, DelValle, John, Yamada, Tadataka (1991/08/15)."Molecular cloning of the human histamine H2 receptor." Biochemical and Biophysical Research Communications 178(3): 1386-1392. <http://hdl.handle.net/2027.42/29176>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WBK-4DNJ4Y4-2J7/2/0f64038a708b4840c58d52756092c166en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29176
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1714721&dopt=citationen_US
dc.description.abstractWe utilized the technique of polymerase chain reaction with oligonucleotide primers based upon the nucleotide sequence of the canine H2 histamine receptor gene which we recently isolated to clone its human homologue. Transfection of a construct of this gene in Colo-320 DM cells led to the expression of a receptor that bound to [methyl-3H] tiotidine and was linked to 3',5' cyclic adenosine monophosphate (cAMP) generation in response to histamine. Both cAMP generation and [methyl-3H] tiotidine binding were inhibited with the H2 histamine receptor selective antagonist cimetidine but not diphenhydramine or thioperamide which are, respectively, H1 and H3 histamine receptor antagonists. These data confirm that we have successfully cloned a novel gene encoding the human H2 histamine receptor.en_US
dc.format.extent739673 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleMolecular cloning of the human histamine H2 receptoren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNatural Resources and Environmenten_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelEcology and Evolutionary Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.contributor.affiliationumDepartment of Physiology, University of Michigan Medical Center, Ann Arbor, MI, USAen_US
dc.identifier.pmid1714721en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29176/1/0000223.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0006-291X(91)91047-Gen_US
dc.identifier.sourceBiochemical and Biophysical Research Communicationsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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