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Bioactive follicle-stimulating hormone

dc.contributor.authorBeitins, Inese Z.en_US
dc.contributor.authorPadmanabhan, Vasanthaen_US
dc.date.accessioned2006-04-10T14:39:59Z
dc.date.available2006-04-10T14:39:59Z
dc.date.issued1991en_US
dc.identifier.citationBeitins, Inese Z., Padmanabhan, Vasantha (1991)."Bioactive follicle-stimulating hormone." Trends in Endocrinology and Metabolism 2(4): 145-151. <http://hdl.handle.net/2027.42/29246>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T3K-4C4FM8H-V/2/0f66b4e2bf7c197d917432ccb298602ben_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29246
dc.description.abstractSpecific and sensitive in vitro bioassays suitable for measurement of follicle-stimulating hormone (FSH) in small quantities of serum and urine have recently been validated. Comparisons of bioassay (B-FSH) potencies with immunoassay (I-FSH) estimates and chromatofocusing patterns have facilitated new discoveries regarding the regulation of FSH biosynthesis, storage, secretion, serum concentrations and target cell responsiveness, plasma clearance, and the significance of excreted forms. A review of recent studies reveals that luteinizing hormone and FSH, as well as B-FSH and I-FSH, appear to be differentially regulated by GnRH, GnRH agonists and antagonists, sex steroids and gonadal peptides in both sexes, with significant differences between the sexes. The results support the overall hypotheses that the quality as well as the quantity of FSH are significant contributors to target cell signal transduction and that distinct FSH isoforms with different functional capabilities influence the expression of acute (ovulation) and chronic reproductive events.en_US
dc.format.extent1239647 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBioactive follicle-stimulating hormoneen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Pediatric Endocrinology at the University of Michigan, Ann Arbor, MI 48109-0718, USAen_US
dc.contributor.affiliationumDivision of Pediatric Endocrinology at the University of Michigan, Ann Arbor, MI 48109-0718, USAen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29246/1/0000303.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/1043-2760(91)90005-8en_US
dc.identifier.sourceTrends in Endocrinology and Metabolismen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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