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Genistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells,

dc.contributor.authorAtluru, Durgaprasadaraoen_US
dc.contributor.authorJackson, Thomas M.en_US
dc.contributor.authorAtluru, Subbayammaen_US
dc.date.accessioned2006-04-10T14:42:32Z
dc.date.available2006-04-10T14:42:32Z
dc.date.issued1991-06en_US
dc.identifier.citationAtluru, Durgaprasadarao, Jackson, Thomas M., Atluru, Subbayamma (1991/06)."Genistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells,." Clinical Immunology and Immunopathology 59(3): 379-387. <http://hdl.handle.net/2027.42/29309>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WCK-4BJW29G-X1/2/0a69adc372a55277b2552fa0b2825ef4en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29309
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1851473&dopt=citationen_US
dc.description.abstractIn this study, genistein, a selective protein tyrosine kinase (PTK) inhibitor, inhibited peripheral blood mononuclear cell (PBMC) proliferation and interleukin-2 production from cultures that were stimulated with phytohemagglutinin (PHA), phorbol 12-myristate 13-acetate (PMA) plus A23187, or PHA plus PMA, and genistein effectively blocked the PHA plus IL-2-induced PBMC proliferation. Further, we also found that genistein inhibited LTB4 production from A23187-stimulated cultures whereas H-7, a PKC inhibitor, had no effect on LTB4 production. Our results suggest that PTK may be necessary for the synthesis of LTB4.en_US
dc.format.extent649557 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleGenistein, a selective protein tyrosine kinase inhibitor, inhibits interleukin-2 and leukotriene B4 production from human mononuclear cells,en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMicrobiology and Immunologyen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumMichigan Diabetes Research and Training Center, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherDepartment of Medicine, Division of Nephrology, Hennepin County Medical Center, 701 Park Ave (RKDP), Minneapolis, Minnesota 55415, USAen_US
dc.contributor.affiliationotherDepartment of Family Practice, University of Minnesota, Minneapolis, Minnesota 55455, USAen_US
dc.identifier.pmid1851473en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29309/1/0000372.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0090-1229(91)90033-7en_US
dc.identifier.sourceClinical Immunology and Immunopathologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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