Oxygen affinity of hemoglobin and peripheral nerve degeneration in experimental diabetes
dc.contributor.author | Farber, Shereen D. | en_US |
dc.contributor.author | Farber, Mark O. | en_US |
dc.contributor.author | Brewer, George J. | en_US |
dc.contributor.author | Magnes, Carolyn J. | en_US |
dc.contributor.author | Peterson, Richard G. | en_US |
dc.date.accessioned | 2006-04-10T14:49:20Z | |
dc.date.available | 2006-04-10T14:49:20Z | |
dc.date.issued | 1991-02 | en_US |
dc.identifier.citation | Farber, Shereen D., Farber, Mark O., Brewer, George, Magnes, Carolyn J., Peterson, Richard G. (1991/02)."Oxygen affinity of hemoglobin and peripheral nerve degeneration in experimental diabetes." Journal of the Neurological Sciences 101(2): 204-207. <http://hdl.handle.net/2027.42/29479> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T06-485YC98-C4/2/0f53889d96dea274a29375c881fa72de | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29479 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2033405&dopt=citation | en_US |
dc.description.abstract | Peripheral neuropathy remains a major complication of diabetes. Numerous etiological theories of metabolic and/or vascular disturbances have been suggested including decreased endoneurial oxygen tension with presumed tissue hypoxia. Increases in the affinity of hemoglobin for oxygen (Hb-O2 affinity) may also produce tissue hypoxia and such Hb-O2 affinity changes have been implicated in the pathogenesis of diabetic microangiopathy. In order to test whether affinity hypoxia might contribute to the development of diabetic peripheral neuropathy, we have utilized a rat model of high and normal Hb-O2 affinity produced by backcrossing animals with increased and decreased levels of 2,3-diphosphoglycerate (DPG). Diabetes was induced in ten high and ten low DPG animals with a tail vein injection of 55 mg/kg streptozotocin (STZ). Five animals in each group were treated with 2.4 U protamine zinc insulin (PZI)/day while the remaining animals were untreated. All rats were killed after 30 days, sections of tibial and sural nerve were rapidly removed and processed for teased fiber analysis. A minimum of 125 axons were assessed per nerve for E degeneration (myelin ovoids) using the classification developed by Dyck et al. Untreated animals, regardless of DPG levels, demonstrated 0% neuropathy. In contrast, all insulin-treated animals showed degeneration (0.4-17%) that inversely correlated with the DPG level (r = -0.59, P 2 affinity) with its attendant effect on tissue oxygen release may play a role in the development of peripheral neuropathy in STZ-induced diabetic rats treated with insulin. | en_US |
dc.format.extent | 395038 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Oxygen affinity of hemoglobin and peripheral nerve degeneration in experimental diabetes | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan Ann Arbor, MI 48109, U.S.A. | en_US |
dc.contributor.affiliationother | Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A. | en_US |
dc.contributor.affiliationother | Roudebush VA Medical Center, Indianapolis, IN 46202, U.S.A. | en_US |
dc.contributor.affiliationother | Roudebush VA Medical Center, Indianapolis, IN 46202, U.S.A. | en_US |
dc.contributor.affiliationother | Indiana University School of Medicine, Indianapolis, IN 46202, U.S.A. | en_US |
dc.identifier.pmid | 2033405 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29479/1/0000565.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0022-510X(91)90047-B | en_US |
dc.identifier.source | Journal of the Neurological Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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