Gene transfer and cardiovascular disease
dc.contributor.author | Nabel, Elizabeth G. | en_US |
dc.contributor.author | Nabel, Gary J. | en_US |
dc.date.accessioned | 2006-04-10T14:50:49Z | |
dc.date.available | 2006-04-10T14:50:49Z | |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Nabel, Elizabeth G., Nabel, Gary J. (1991)."Gene transfer and cardiovascular disease." Trends in Cardiovascular Medicine 1(1): 12-17. <http://hdl.handle.net/2027.42/29517> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T1D-4BWVWM6-62/2/516890c7e1b0989ec321a0e202e6e743 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29517 | |
dc.description.abstract | Through the introduction of foreign DNA into somatic cells, the aim of gene therapy is to correct or prevent disorders caused by the absence or malfunction of genes within a diseased individual. Expression of recombinant genes at specific sites within the vasculature can provide insights into vascular biology and potential treatments for various cardiovascular disorders. In our studies, we have developed methods for the transfer of recombinant genes into the endothelium and vascular smooth muscle cells by using retroviral vectors and liposomal transfection. Although these techniques are still in the formative stages, gene transfer into the endothelium and other vascular cells is a new approach to the treatment of vascular diseases, including atherosclerosis and restenosis. | en_US |
dc.format.extent | 1170317 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Gene transfer and cardiovascular disease | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Cardiology, Department of Internal Medicine; Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109-0688, USA | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Biochemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109-0688, USA | en_US |
dc.identifier.pmid | 21239340 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29517/1/0000604.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/1050-1738(91)90053-H | en_US |
dc.identifier.source | Trends in Cardiovascular Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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