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| Title: | Induction of NF-[chi]B during monocyte differentiation is associated with activation of HIV-gene expression |
| Authors: | Griffin, G. E.
Leung, Kwanyee
Folks, T. M.
Kunkel, S.
Nabel, Gary J. |
| Issue Date: | 1991 |
| Publisher: | Elsevier |
| Citation: | Griffin, G. E., Leung, K., Folks, T. M., Kunkel, S., Nabel, G. J. (1991)."Induction of NF-[chi]B during monocyte differentiation is associated with activation of HIV-gene expression." Research in Virology 142(2-3): 233-238. <http://hdl.handle.net/2027.42/29580> |
| Abstract: | Cells of the monocyte-macrophage lineage are important targets of HIV infection. We report here that the phenotypic differentiation of monocyte cell lines induced by phorbol esters or tumour necrosis factor [alpha] (TNF[alpha]) is associated with expression of nuclear factor kappa B (NF-[chi]B). In parallel with such differentiation, HIV transcription, monitored using an HIV long terminal repeat reporter gene construct, is activated in such cells under the influence of enhanced NF-[chi]B expression. Also, in a promonocyte cell line chronically infected with HIV, NF-[chi]B expression and HIV transcription were enhanced on stimulation with phorbol ester or TNF[alpha]. Thus, stimulation of monocyte cell lines by phorbol esters or TNF[alpha] induces cell differentiation and activates HIV transcription. Such a process may have fundamental implications in AIDS pathogenesis in vivo and may be important in disease progression induced by opportunistic infections directly or indirectly involving macrophages. |
| URI: | http://www.sciencedirect.com/science/article/B6VN4-47DKXTM-1
W/2/0d9a0f085e894926c1fdb9d0fe285b9d
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db
=pubmed&list_uids=1896645&dopt=citation |
| DOI: | 10.1016/0923-2516(91)90062-8 |
| PMID: | 1896645 |
| Appears in Collections: | Interdisciplinary and Peer-Reviewed
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