A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus
dc.contributor.author | Frazer, Kelly A. | en_US |
dc.contributor.author | Boehnke, Michael | en_US |
dc.contributor.author | Budarf, Marcia L. | en_US |
dc.contributor.author | Wolff, Roger K. | en_US |
dc.contributor.author | Emanuel, Beverly S. | en_US |
dc.contributor.author | Myers, Richard M. | en_US |
dc.contributor.author | Cox, David R. | en_US |
dc.date.accessioned | 2006-04-10T15:01:17Z | |
dc.date.available | 2006-04-10T15:01:17Z | |
dc.date.issued | 1992-11 | en_US |
dc.identifier.citation | Frazer, Kelly A., Boehnke, Michael, Budarf, Marcia L., Wolff, Roger K., Emanuel, Beverly S., Myers, Richard M., Cox, David R. (1992/11)."A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus." Genomics 14(3): 574-584. <http://hdl.handle.net/2027.42/29761> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4GSCHKG-4/2/f31e36f8042528fab774cdeda6104815 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29761 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1427886&dopt=citation | en_US |
dc.description.abstract | We describe a high-resolution radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 (NF2) gene. Eighty-five hamster--human somatic cell hybrids generated by X-irradiation and cell fusion were used to generate the radiation hybrid map. The presence or absence of 18 human chromosome 22-specific markers was determined in each hybrid by using Southern blot hybridization. Sixteen of the 18 markers were distinguishable by X-ray breakage in the radiation hybrids. Analysis of these data using two different mathematical models and two different statistical methods resulted in a single framework map consisting of 8 markers ordered with odds greater than 1000:1. The remaining nonframework markers were all localized to regions consisting of two adjoining intervals on the framework map with odds greater than 1000:1. Based on the RH map, the NF2 region of chromosome 22, defined by the flanking markers D22S1 and D22S28, is estimated to span a physical distance of approximately 6 Mb and is the most likely location for 9 of the 18 markers studied: D22S33, D22S41, D22S42, D22S46, D22S56, LIF, D22S37, D22S44, and D22S15. | en_US |
dc.format.extent | 1203297 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationother | Department of Anatomy, University of California, San Francisco, California, 94143, USA | en_US |
dc.contributor.affiliationother | Pediatrics and Human Genetics, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of California, San Francisco, California, 94143, USA | en_US |
dc.contributor.affiliationother | Pediatrics and Human Genetics, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA | en_US |
dc.contributor.affiliationother | Department of Physiology, University of California, San Francisco, California, 94143, USA | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of California, San Francisco, California, 94143, USA; Department of Physiology, University of California, San Francisco, California, 94143, USA. | en_US |
dc.identifier.pmid | 1427886 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29761/1/0000099.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/S0888-7543(05)80154-5 | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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