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Isolation of a yeast artificial chromosome clone that spans the (12;16) translocation breakpoint characteristic of myxoid liposarcoma
Gemmill, Robert M.; Mendez, Michael J.; Dougherty, Cynthia M.; Paulien, Sylvie; Liao, Martha; Mitchell, Deanna; Jankowski, Sheryl A.; Trent, Jeffrey M.; Berger, Carol S.; Sandberg, Avery A.; Meltzer, Paul S.
1992-09
Citation:Gemmill, Robert M., Mendez, Michael J., Dougherty, Cynthia M., Paulien, Sylvie, Liao, Martha, Mitchell, Deanna, Jankowski, Sheryl A., Trent, Jeffrey M., Berger, Carol, Sandberg, Avery A., Meltzer, Paul S. (1992/09)."Isolation of a yeast artificial chromosome clone that spans the (12;16) translocation breakpoint characteristic of myxoid liposarcoma." Cancer Genetics and Cytogenetics 62(2): 166-170. <http://hdl.handle.net/2027.42/29862>
Abstract: Cytogenetic analysis of liposarcomas has demonstrated that translocation (12;16) (q13.3;p11.2) is characteristic of the myxoid subtype of this adipose tissue tumor. Our previous results suggested that the GLI gene is close to the translocation breakpoint on chromosome 12. We now describe a yeast artificial chromosome (YAC) that contains GLI and spans the chromosome 12 region involved in the t(12;16) breakpoint. This clone will permit rapid definition of the genetic region surrounding the breakpoint and allow isolation of the gene presumably affected by the translocation.
