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Potential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agent

dc.contributor.authorSchwendner, Susan W.en_US
dc.contributor.authorWeichert, Jamey P.en_US
dc.contributor.authorLongino, Marc A.en_US
dc.contributor.authorGross, Milton D.en_US
dc.contributor.authorCounsell, Raymond E.en_US
dc.date.accessioned2006-04-10T15:08:31Z
dc.date.available2006-04-10T15:08:31Z
dc.date.issued1992-08en_US
dc.identifier.citationSchwendner, S. W., Weichert, J. P., Longino, M. A., Gross, M. D., Counsell, R. E. (1992/08)."Potential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agent." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 19(6): 639-647. <http://hdl.handle.net/2027.42/29932>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B7GH9-4C00NH8-5X/2/6afc5fadf62624336fe37c8206dfaeceen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29932
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1522018&dopt=citationen_US
dc.description.abstractA triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these groups. Similar results were observed by [gamma] -camera scintigraphy. Comparing the uptake of DPPG with that of its fatty acid component, 15-(p-iodophenyl)pentadecanoic acid (IPPA), revealed that the peak uptake of IPPA in the liver was about half that of DPPG. Based upon these findings, DPPG warrants further study as a hepatic radiodiagnostic agent.en_US
dc.format.extent1461287 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titlePotential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agenten_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPhysicsen_US
dc.subject.hlbsecondlevelNuclear Engineering and Radiological Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelEngineeringen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, U.S.A.en_US
dc.contributor.affiliationumDepartment of Pharmacology, M6322 Medical Science I, University of Michigan Medical School, Ann Arbor, MI 48109-0626, U.S.A.en_US
dc.contributor.affiliationotherNuclear Medicine Unit, VA Medical Center, Ann Arbor, MI 48104, U.S.A.en_US
dc.identifier.pmid1522018en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29932/1/0000289.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0883-2897(92)90098-Jen_US
dc.identifier.sourceInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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