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Identification of new markers in Xp21 between DXS28 (C7) and DMD
dc.contributor.authorWorley, K. C.en_US
dc.contributor.authorTowbin, Jeffrey A.en_US
dc.contributor.authorZhu, X. M.en_US
dc.contributor.authorBarker, D. F.en_US
dc.contributor.authorBallabio, Andreaen_US
dc.contributor.authorChamberlain, Jeffrey S.en_US
dc.contributor.authorBiesecker, Leslie G.en_US
dc.contributor.authorBlethen, S. L.en_US
dc.contributor.authorBrosnan, P.en_US
dc.contributor.authorFox, J. E.en_US
dc.date.accessioned2006-04-10T15:08:38Z
dc.date.available2006-04-10T15:08:38Z
dc.date.issued1992-08en_US
dc.identifier.citationWorley, K. C., Towbin, J. A., Zhu, X. M., Barker, D. F., Ballabio, A., Chamberlain, J., Biesecker, L. G., Blethen, S. L., Brosnan, P., Fox, J. E. (1992/08)."Identification of new markers in Xp21 between DXS28 (C7) and DMD." Genomics 13(4): 957-961. <http://hdl.handle.net/2027.42/29935>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DNHP53-35/2/1d8215267252b7ec16b0b040b1886182en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/29935
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1505987&dopt=citationen_US
dc.description.abstractCharacterization of Xp21 distal to Duchenne muscular dystrophy (DMD) in the region containing the genes for adrenal hypoplasia congenita (AHC) and glycerol kinase deficiency (GKD) has been limited due to a paucity of probes. Two probes were localized between DXS28 (C7) and AHC, the yeast artificial chromosome insert YHX39 (DXS727) and the polymorphic phage clone QST59 (DXS319). A genomic clone, FT1 (DXS726), 3' to DMD, was also characterized. Portions of the three probes were sequenced and primer pairs were generated to amplify a sequence-tagged site within each probe. Amplification of DNA from patients confirmed the deletion results obtained by Southern blot analysis, and these three sequence-tagged sites were successfully combined for triplex PCR. In addition to facilitating molecular genetic diagnosis in Xp21, these probes can be used to identify additional YACs and other probes to further increase the genomic information and diagnostic capabilities in this region.en_US
dc.format.extent1378006 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleIdentification of new markers in Xp21 between DXS28 (C7) and DMDen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumDivision of Pediatric Genetics, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherInstitute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAen_US
dc.contributor.affiliationotherDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USAen_US
dc.contributor.affiliationotherInstitute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAen_US
dc.contributor.affiliationotherGenetic Epidemiology, University of Utah, Salt Lake City, Utah 84108, USAen_US
dc.contributor.affiliationotherInstitute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAen_US
dc.contributor.affiliationotherno department founden_US
dc.contributor.affiliationotherDriscol Foundation Children's Hospital, Corpus Christi, Texas 78466, USAen_US
dc.contributor.affiliationotherSchneider Children's Hospital, New Hyde Park, New York 11042, USAen_US
dc.identifier.pmid1505987en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/29935/1/0000292.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(92)90007-Fen_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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