A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene
dc.contributor.author | Marchuk, Douglas A. | en_US |
dc.contributor.author | Tavakkol, Roxanne | en_US |
dc.contributor.author | Wallace, Margaret R. | en_US |
dc.contributor.author | Brownstein, Bernard H. | en_US |
dc.contributor.author | Taillon-Miller, Patricia | en_US |
dc.contributor.author | Fong, Chin-To | en_US |
dc.contributor.author | Legius, Eric | en_US |
dc.contributor.author | Andersen, Lone B. | en_US |
dc.contributor.author | Glover, Thomas W. | en_US |
dc.contributor.author | Collins, Francis S. | en_US |
dc.date.accessioned | 2006-04-10T15:10:10Z | |
dc.date.available | 2006-04-10T15:10:10Z | |
dc.date.issued | 1992-07 | en_US |
dc.identifier.citation | Marchuk, Douglas A., Tavakkol, Roxanne, Wallace, Margaret R., Brownstein, Bernard H., Taillon-Miller, Patricia, Fong, Chin-To, Legius, Eric, Andersen, Lone B., Glover, Thomas W., Collins, Francis S. (1992/07)."A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene." Genomics 13(3): 672-680. <http://hdl.handle.net/2027.42/29972> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6WG1-4DNHS2F-PH/2/689930a698648482950690532e5a391a | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/29972 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1639394&dopt=citation | en_US |
dc.description.abstract | The yeast artificial chromosome (YAC) system (Burke et al., 1987, Science 236: 806-812) allows the direct cloning of large regions of the genome. A YAC contig map of approximately 700 kb encompassing the region surrounding the type 1 neurofibromatosis (NF1) locus on 17q11.2 has been constructed. A single YAC containing the entire NF1 locus has been constructed by homologous recombination in yeast. In the process of contig construction a novel method of YAC end rescue has been developed by YAC circularization in yeast and plasmid rescue in bacteria. YACs containing homology to the NF1 region but mapping to another chromosome have also been discovered. Sequences of portions of the homologous locus indicate that this other locus is a nonprocessed pseudogene. | en_US |
dc.format.extent | 3101388 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA | en_US |
dc.contributor.affiliationum | Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. | en_US |
dc.contributor.affiliationother | Center for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri 63130, USA | en_US |
dc.contributor.affiliationother | Center for Genetics in Medicine, Washington University School of Medicine, St. Louis, Missouri 63130, USA | en_US |
dc.contributor.affiliationother | Department of Pediatric Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA | en_US |
dc.identifier.pmid | 1639394 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/29972/1/0000334.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0888-7543(92)90140-N | en_US |
dc.identifier.source | Genomics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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