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Related subunits of NF-[kappa]B map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2

dc.contributor.authorLiptay, Susanneen_US
dc.contributor.authorSchmid, Roland M.en_US
dc.contributor.authorPerkins, Neil D.en_US
dc.contributor.authorMeltzer, Paul S.en_US
dc.contributor.authorAltherr, Michael R.en_US
dc.contributor.authorMcPherson, John D.en_US
dc.contributor.authorWasserman, Arthur G.en_US
dc.contributor.authorNabel, Gary J.en_US
dc.date.accessioned2006-04-10T15:11:41Z
dc.date.available2006-04-10T15:11:41Z
dc.date.issued1992-06en_US
dc.identifier.citationLiptay, Susanne, Schmid, Roland M., Perkins, Neil D., Meltzer, Paul, Altherr, Michael R., McPherson, John D., Wasmuth, John J., Nabel, Gary J. (1992/06)."Related subunits of NF-[kappa]B map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2." Genomics 13(2): 287-292. <http://hdl.handle.net/2027.42/30009>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DYM8X6-3X/2/9598cd47447e1da1ef34c4f6f979f7a2en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30009
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1612589&dopt=citationen_US
dc.description.abstractThe chromosomal locations of the human genes NFKB1 and NFKB2, which encode two alternative DNA binding subunits of the NF-[kappa]B complex, p105 and p49/p100, respectively, have been determined. p105 was assigned to 4q21.1-q24 and p49/p100 to chromosome 10 by Southern blot analysis of panels of human/Chinese hamster cell hybrids. The locations were confirmed by fluorescence in situ hybridization and mapped with greater resolution to 4q23 and 10q24, respectively. These results demonstrate that these members of the NF-[kappa]B family are unlinked. Interestingly, p49/p100 as well as p105 maps to regions associated with certain types of acute lymphoblastic leukemia.en_US
dc.format.extent2448091 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleRelated subunits of NF-[kappa]B map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of California, Irvine, California 92717, USA; Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of California, Irvine, California 92717, USA; Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of California, Irvine, California 92717, USA; Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA.en_US
dc.contributor.affiliationumDepartment of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationumDepartment of Pediatrics and Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USAen_US
dc.contributor.affiliationumDepartment of Pediatrics and Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USAen_US
dc.contributor.affiliationumDepartment of Pediatrics and Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USAen_US
dc.contributor.affiliationumHoward Hughes Medical Institute, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USAen_US
dc.identifier.pmid1612589en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30009/1/0000377.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(92)90244-Men_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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