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Sequence-tagged sites (STSs) spanning 4p16.3 and the Huntington disease candidate region

dc.contributor.authorGusella, James F.en_US
dc.contributor.authorAltherr, Michael R.en_US
dc.contributor.authorMcClatchey, Andrea I.en_US
dc.contributor.authorDoucette-Stamm, Lynn A.en_US
dc.contributor.authorTagle, Danen_US
dc.contributor.authorPlummer, Sarahen_US
dc.contributor.authorGroot, Nicoleten_US
dc.contributor.authorBarnes, Glennen_US
dc.contributor.authorHummerich, Holgeren_US
dc.contributor.authorCollins, Francis S.en_US
dc.date.accessioned2006-04-10T15:13:53Z
dc.date.available2006-04-10T15:13:53Z
dc.date.issued1992-05en_US
dc.identifier.citationGusella, James F., Altherr, Michael R., McClatchey, Andrea I., Doucette-Stamm, Lynn A., Tagle, Dan, Plummer, Sarah, Groot, Nicolet, Barnes, Glenn, Hummerich, Holger, Collins, Francis S. (1992/05)."Sequence-tagged sites (STSs) spanning 4p16.3 and the Huntington disease candidate region." Genomics 13(1): 75-80. <http://hdl.handle.net/2027.42/30062>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6WG1-4DYM8X6-2G/2/db0e76c54f63894ef977a5791d320346en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30062
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1533609&dopt=citationen_US
dc.description.abstractThe generation of sequence-tagged sites (STSs) has been proposed as a unifying approach to correlating the disparate results generated by genetic and various physical techniques being used to map the human genome. We have developed an STS map to complement the existing physical and genetic maps of 4p16.3, the region containing the Huntington disease gene. A total of 18 STSs span over 4 Mb of 4p16.3, with an average spacing of about 250 kb. Eleven of the STSs are located within the primary candidate HD region of 2.5 Mb between D4S126 and D4S168. The availability of STSs makes the corresponding loci accessible to the general community without the need for distribution of cloned DNA. These STSs should also provide the means to isolate yeast artificial chromosome clones spanning the HD candidate region.en_US
dc.format.extent981158 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleSequence-tagged sites (STSs) spanning 4p16.3 and the Huntington disease candidate regionen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumHoward Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationumHoward Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan 48109, USAen_US
dc.contributor.affiliationotherDepartment of Genetics, Harvard Medical School, Charlestown, Massachusetts 02129, USAen_US
dc.contributor.affiliationotherDepartment of Biological Chemistry, University of California, Irvine, California 92717, USAen_US
dc.contributor.affiliationotherDepartment of Genetics, Harvard Medical School, Charlestown, Massachusetts 02129, USAen_US
dc.contributor.affiliationotherCenter for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USAen_US
dc.contributor.affiliationotherDepartment of Biological Chemistry, University of California, Irvine, California 92717, USAen_US
dc.contributor.affiliationotherDepartment of Genetics, Harvard Medical School, Charlestown, Massachusetts 02129, USAen_US
dc.contributor.affiliationotherDepartment of Genetics, Harvard Medical School, Charlestown, Massachusetts 02129, USAen_US
dc.contributor.affiliationotherImperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, United Kingdomen_US
dc.identifier.pmid1533609en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30062/1/0000432.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0888-7543(92)90204-6en_US
dc.identifier.sourceGenomicsen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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