A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice

Sweet, Ann; Erickson, Robert P.; Huntington, Caleb; Dawson, David C.

1992-02

Citation: Sweet, Ann, Erickson, Robert P., Huntington, Caleb, Dawson, David (1992/02)."A potential animal model for studying CF heterozygote advantage: Genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice." Biochemical Medicine and Metabolic Biology 47(1): 97-102. <http://hdl.handle.net/2027.42/30220>

Abstract: We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA/2J than in the C57BL/6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL/6J parental strain while colonic segments from five recombinant inbred B x D lines ranged between the C57BL/6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.

DOIs: http://dx.doi.org/10.1016/0885-4505(92)90011-M

PMID: 1562359

URI: http://www.sciencedirect.com/science/article/B6WBN-4C4NS9N-22/2/ae05a1d4ec16fad44002f329367f3a81
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1562359&dopt=citation

Handle: http://hdl.handle.net/2027.42/30220

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