T-lymphocyte activation in adult-onset idiopathic hypoparathyroidism
dc.contributor.author | Wortsman, Jacobo | en_US |
dc.contributor.author | McConnachie, Peter | en_US |
dc.contributor.author | Baker, Jr. , James R. | en_US |
dc.contributor.author | Mallette, Lawrence E. | en_US |
dc.date.accessioned | 2006-04-10T15:25:42Z | |
dc.date.available | 2006-04-10T15:25:42Z | |
dc.date.issued | 1992-04 | en_US |
dc.identifier.citation | Wortsman, Jacobo, McConnachie, Peter, Baker, Jr., James R., Mallette, Lawrence E. (1992/04)."T-lymphocyte activation in adult-onset idiopathic hypoparathyroidism." The American Journal of Medicine 92(4): 352-356. <http://hdl.handle.net/2027.42/30341> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6TDC-4CMYVCH-BV/2/ecc5f91a92375d77851d8f397a18ef2e | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30341 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1348395&dopt=citation | en_US |
dc.description.abstract | : Patients with adult-onset idiopathic hypoparathyroidism (AOIH) often have antibodies against the parathyroid glands and other tissues, suggestive of immune activation. The purpose of this study was to determine whether T-cell activation is also a component of the endocrine disease.: We identified eight patients with idiopathic hypoparathyroidism diagnosed after the age of 30 years at two tertiary care centers and evaluated peripheral blood lymphocyte subset phenotype frequencies using monoclonal antibodies and flow cytometry. Control subjects were 13 patients with Graves' disease (five thyrotoxic and eight euthyroid) and 110 healthy volunteers. In two of the patients with AOIH, we also determined the mitogenic response to parathyroid cell membranes in peripheral lymphocytes.: Patients with AOIH had higher than normal frequencies of the following phenotypes (p : Generalized T-cell activation represents a novel feature associated with AOIH. Although we could not demonstrate parathyroid-specific lymphocyte clonal expansion, these data are suggestive of a generalized immune disturbance possibly related to autoimmunity, in which one of the manifestations is hypoparathyroidism. | en_US |
dc.format.extent | 689578 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | T-lymphocyte activation in adult-onset idiopathic hypoparathyroidism | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Family Medicine and Primary Care | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Southern Illinois University, Springfield, Illinois, USA | en_US |
dc.contributor.affiliationother | Medical Microbiology-Immunology, Southern Illinois University, Springfield, Illinois, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, Baylor College of Medicine and Veterans Administration Medical Center, Houston, Texas, USA | en_US |
dc.identifier.pmid | 1348395 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30341/1/0000743.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0002-9343(92)90263-B | en_US |
dc.identifier.source | The American Journal of Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.