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Basal extracellular dopamine in the nucleus accumbens during amphetamine withdrawal: a `no net flux' microdialysis study

dc.contributor.authorCrippens, Donitaen_US
dc.contributor.authorCamp, Dianne M.en_US
dc.contributor.authorRobinson, Terry E.en_US
dc.date.accessioned2006-04-10T15:27:55Z
dc.date.available2006-04-10T15:27:55Z
dc.date.issued1993-12-24en_US
dc.identifier.citationCrippens, Donita, Camp, Dianne M., Robinson, Terry E. (1993/12/24)."Basal extracellular dopamine in the nucleus accumbens during amphetamine withdrawal: a `no net flux' microdialysis study." Neuroscience Letters 164(1-2): 145-148. <http://hdl.handle.net/2027.42/30384>en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/B6T0G-482RD3S-8M/2/3e74a099b57ca703b75315b2763f76e1en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/30384
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8152590&dopt=citationen_US
dc.description.abstractThe basal extracellular concentration of dopamine in the nucleus accumbens was quantified using the `no net flux' microdialysis method, in rats undergoing withdrawal from -amphetamine. Rats were initially pretreated with saline, or an escalating dose amphetamine regimen known to produce a robust withdrawal syndrome, and extracellular dopamine was quantified 3 or 28 days after the last pretreatment injection. There was no effect of amphetamine pretreatment on the basal extracellular concentration of dopamine in the nucleus accumbens, or on the `in vivo recovery' of dopamine, estimated by `no net flux' microdialysis. It is suggested that amphetamine withdrawal is not necessarily accompanied by changes in the basal extracellular concentration of dopamine in the nucleus accumbens.en_US
dc.format.extent414718 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherElsevieren_US
dc.titleBasal extracellular dopamine in the nucleus accumbens during amphetamine withdrawal: a `no net flux' microdialysis studyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPublic Healthen_US
dc.subject.hlbsecondlevelPsychologyen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelSocial Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychology, The University of Michigan, Ann Arbor, MI., USAen_US
dc.contributor.affiliationumDepartment of Psychology, The University of Michigan, Ann Arbor, MI., USAen_US
dc.contributor.affiliationumDepartment of Psychology, The University of Michigan, Ann Arbor, MI., USA; Department of Neuroscience Program, The University of Michigan, Ann Arbor, MI., USAen_US
dc.identifier.pmid8152590en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/30384/1/0000002.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1016/0304-3940(93)90878-Oen_US
dc.identifier.sourceNeuroscience Lettersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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