Osmotic pump implant for chronic infusion of drugs into the inner ear
dc.contributor.author | Brown, J. Nadine | en_US |
dc.contributor.author | Miller, Josef M. | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.contributor.author | Nuttall, Alfred L. | en_US |
dc.date.accessioned | 2006-04-10T15:31:07Z | |
dc.date.available | 2006-04-10T15:31:07Z | |
dc.date.issued | 1993-11 | en_US |
dc.identifier.citation | Brown, J. Nadine, Miller, Josef M., Altschuler, Richard A., Nuttall, Alfred L. (1993/11)."Osmotic pump implant for chronic infusion of drugs into the inner ear." Hearing Research 70(2): 167-172. <http://hdl.handle.net/2027.42/30463> | en_US |
dc.identifier.uri | http://www.sciencedirect.com/science/article/B6T73-487CV5R-3D/2/7b1965f150ad453f26678738304d2995 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/30463 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8294261&dopt=citation | en_US |
dc.description.abstract | Continuous long-term delivery of experimental drugs to the cochlea of a small animal, such as a young guinea pig, presents several technical problems. A method of placing and securing a cannula-osmotic pump system is described in this paper. Guinea pigs (225-410 g) were unilaterally implanted with an Alzet micro-pump and cannula for delivery of 20 mM tetrodotoxin (TTX) (six animals) or saline (three animals) for three days (1 [mu]l/h). Auditory brainstem responses (ABRs) were recorded under light anesthesia on post-implant day 1 and day 3 and compared with pre-implant baseline values. In all six cochleas infused with TTX, most frequencies showed a 30-60dB decrease in sensitivity within 24 h. Saline control animals showed little or no change from baseline sensitivity for most frequencies. In three TTX-infused animals, the cannula-pump unit was removed on day 3, and ABRs were followed during recovery. Most frequencies returned to, or near, pre-implant levels after pump removal but recovery times varied. By day 6, all animals had recovered post-surgical weight loss and showed a gain of 10-40 g. Brains and cochleas were removed and processed for sectioning. Assessment of the cochlear nucleus of non-recovery TTX-treated animals showed a deafness-related flattening of auditory nerve active zones on the treated side. | en_US |
dc.format.extent | 711334 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | en_US |
dc.title | Osmotic pump implant for chronic infusion of drugs into the inner ear | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-05065, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-05065, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-05065, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-05065, USA | en_US |
dc.identifier.pmid | 8294261 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/30463/1/0000091.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1016/0378-5955(93)90155-T | en_US |
dc.identifier.source | Hearing Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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